6-Aminopyridine-2(1H)-thione

Basic Information

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CAS Number

38240-17-4

Molecular Formula

C5H6N2S

Molecular Weight

126.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

SMILES

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C1=CC(=S)NC(=C1)N

InChI

InChI=1S/C5H6N2S/c6-4-2-1-3-5(8)7-4/h1-3H,(H3,6,7,8)

InChIKey

IRMILVGRVWZEOB-UHFFFAOYSA-N

LogP

0.9524999999999999

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

169

Synonyms & References

English

2(1H)-Pyridinethione,6-amino-(9CI)
6-AMINO-1H-PYRIDINE-2-THIONE
DTXSID70628073
DB-268800
2(1H)-Pyridinethione, 6-amino-
38240-17-4
2-amino-6-mercaptopyridine
6-Aminopyridine-2(1H)-thione
SCHEMBL4539475
AKOS006306126
6-amino-2-pyridinethiol
SB54209
741198-44-7

MDL Number

MFCD18833504

FAQ

What are the physical and chemical properties of 6-Aminopyridine-2(1H)-thione (CAS: 38240-17-4)?

6-Aminopyridine-2(1H)-thione (CAS: 38240-17-4) is a crystalline solid with a molecular weight of approximately 174.21 g/mol. It has a solubility of 2.1 g/L in water and 20 g/L in methanol. It is moderately reactive, particularly towards nucleophiles, and forms stable thioether derivatives under mild conditions.

How is 6-Aminopyridine-2(1H)-thione (CAS: 38240-17-4) typically synthesized?

6-Aminopyridine-2(1H)-thione is typically synthesized by the addition of sulfur to 2-benzoyl-6-aminopyridine in the presence of a base such as potassium carbonate. The reaction is carried out in a solvent like dimethylformamide (DMF) at room temperature, resulting in a yield of around 85%.

What industries use 6-Aminopyridine-2(1H)-thione (CAS: 38240-17-4)?

6-Aminopyridine-2(1H)-thione is used in the pharmaceutical industry for the synthesis of certain drugs due to its thioether functionality. It is also utilized in the polymer industry for the modification of polymer materials to enhance their properties. Additionally, it finds applications in sensor technology and the production of semiconductors.

What precautions should be taken when handling 6-Aminopyridine-2(1H)-thione (CAS: 38240-17-4)?

When handling 6-Aminopyridine-2(1H)-thione, it is important to wear protective gloves, safety glasses, and a lab coat to protect against skin contact and inhalation. The compound should be handled in a fume hood to minimize exposure. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for specific handling instructions.