6-Aminopyridine-2(1H)-thione(CAS: 38240-17-4)

6-Aminopyridine-2(1H)-thione (CAS: 38240-17-4) is a crystalline solid with a molecular weight of approximately 174.21 g/mol. It has a solubility of 2.1 g/L in water and 20 g/L in methanol. It is moderately reactive, particularly towards nucleophiles, and forms stable thioether derivatives under mild conditions.

6-Aminopyridine-2(1H)-thione is typically synthesized by the addition of sulfur to 2-benzoyl-6-aminopyridine in the presence of a base such as potassium carbonate. The reaction is carried out in a solvent like dimethylformamide (DMF) at room temperature, resulting in a yield of around 85%.

6-Aminopyridine-2(1H)-thione is used in the pharmaceutical industry for the synthesis of certain drugs due to its thioether functionality. It is also utilized in the polymer industry for the modification of polymer materials to enhance their properties. Additionally, it finds applications in sensor technology and the production of semiconductors.

When handling 6-Aminopyridine-2(1H)-thione, it is important to wear protective gloves, safety glasses, and a lab coat to protect against skin contact and inhalation. The compound should be handled in a fume hood to minimize exposure. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for specific handling instructions.