4-Methyl-2,6-bis(2-methyl-2-propanyl)pyridine

Basic Information

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CAS Number

38222-83-2

Molecular Formula

C14H23N

Molecular Weight

205.34 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

33-36 °C

Boiling Point

226°C

Water Solubility

Sparingly soluble in water. Soluble in ethanol, acetic acid and diethyl ether.

Solubility

ethanol: soluble5%, clear to slightly hazy, colorless to dark yellow

Refractive Index

n20/D 1.4763(lit.)

SMILES

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CC1=CC(=NC(=C1)C(C)(C)C)C(C)(C)C

InChI

InChI=1S/C14H23N/c1-10-8-11(13(2,3)4)15-12(9-10)14(5,6)7/h8-9H,1-7H3

InChIKey

HVHZEKKZMFRULH-UHFFFAOYSA-N

LogP

3.985020000000003

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

184

Safety Information

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GHS Hazard Pictograms

H302

H315

H319

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

Air & Light Sensitive

Synonyms & References

English

NSC175792
AE-562/42754364
SY005669
2,6-di-tert-butyl4-methyl-pyridine
2,6-di(tert-butyl)-4-methylpyridine
TS-00365
DTBMP
HY-W007500
AMY15615
UNII-83004E89V5
FT-0639442
AC1509
2,6-Di-tert-butyl-4-methylpyridine
IDINE, 2,6-BIS(1,1-DIMETHYLETHYL)-4-METHYL-
2,6-di-tertbutyl-4-methyl-pyridine
2,6-di-tert-butyl-4-picoline
2,6-di-tert-butyl-4-methyl pyridine
EN300-316978
W-202564
83004E89V5
AKOS015838101
AC-5133
2,6-di-tert-butyl-4methylpyridine
A824064
2,6-di-t-butyl-4-methyl pyridine
2,6-di-t-butyl 4-methylpyridine
2,6-DI-TERT-BUTYL-4-METHYLPYRIDINE [MI]
NSC-175792
EINECS 253-834-4
2,6-di-t-Butyl-4-methylpyridine
SCHEMBL37832

MDL Number

MFCD00006305

Customs Code

2942000000

FAQ

What are the physical and chemical properties of 4-Methyl-2,6-bis(2-methyl-2-propanyl)pyridine (CAS: 38222-83-2)?

4-Methyl-2,6-bis(2-methyl-2-propanyl)pyridine is a white crystalline solid with a molecular weight of approximately 234.33 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly towards nucleophiles and reducing agents. The compound can form stable solutions in polar solvents and is known for its stability under normal storage conditions.

How is 4-Methyl-2,6-bis(2-methyl-2-propanyl)pyridine (CAS: 38222-83-2) typically synthesized?

4-Methyl-2,6-bis(2-methyl-2-propanyl)pyridine can be synthesized via a multi-step process involving the alkylation of pyridine with 2-methyl-2-propanol followed by amination. The reaction typically proceeds under mild conditions using a suitable catalyst, such as a Lewis acid, and the overall yield can be as high as 85%. The exact conditions, including temperature and pressure, can vary depending on the specific method chosen.

What industries use 4-Methyl-2,6-bis(2-methyl-2-propanyl)pyridine (CAS: 38222-83-2)?

4-Methyl-2,6-bis(2-methyl-2-propanyl)pyridine is utilized in the pharmaceutical industry for the synthesis of certain active pharmaceutical ingredients (APIs) due to its unique chemical properties. It also finds applications in the polymer industry as a stabilizer and in the development of sensors for detecting specific chemical or biological agents. Additionally, it is used in the semiconductor industry as a precursor in the fabrication of electronic materials.

What precautions should be taken when handling 4-Methyl-2,6-bis(2-methyl-2-propanyl)pyridine (CAS: 38222-83-2)?

When handling 4-Methyl-2,6-bis(2-methyl-2-propanyl)pyridine, it is crucial to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a laboratory coat. The compound should be stored in a cool, dry place away from direct sunlight and should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. In case of a spill, immediately evacuate the area and contact the appropriate safety personnel. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.