1,3,5-Trifluorobenzene

Basic Information

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CAS Number

372-38-3

Molecular Formula

C6H3F3

Molecular Weight

132.08 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

−5.5 °C

Boiling Point

76°C

Water Solubility

Insoluble in water.

Refractive Index

n20/D 1.414(lit.)

SMILES

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C1=C(C=C(C=C1F)F)F

InChI

InChI=1S/C6H3F3/c7-4-1-5(8)3-6(9)2-4/h1-3H

InChIKey

JXUKFFRPLNTYIV-UHFFFAOYSA-N

LogP

2.1039000000000003

Topological Polar Surface Area

0.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 0

Complexity

63.3

Safety Information

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Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 3 Class 3

Synonyms & References

English

NSC10264
T1039
FT-0606510
1,3,5-Trifluorobenzene, 97%
1,3,5-TRIFLUOROBENZENE
4-(DIHEXYLAMINO)BENZOICACID
NS00041741
NSC-10264
DTXSID90190686
UNII-BN94C411F8
Benzene,3,5-trifluoro-
1,3,5-TRIFLUORO BENZENE
1,5-Trifluorobenzene
EINECS 206-751-2
A823578
Q27274766
1,3,5-Trifluorobenzene #
EN300-25659
1,3,5-tri-fluorobenzene
BN94C411F8
sym-Trifluorobenzene
MFCD00000333
W-106556
SCHEMBL449836
PS-10252
AKOS005258293
Benzene, 1,3,5-trifluoro-
372-38-3
NSC 10264
AMY12436
1,3,5-Trifluorobenzene

MDL Number

MFCD00000333

Customs Code

2903999090

FAQ

What is 1,3,5-Trifluorobenzene (CAS: 372-38-3)?

1,3,5-Trifluorobenzene (CAS: 372-38-3) is a fluorinated aromatic compound with the chemical formula C6H3F3. It is a colorless liquid with a high melting point (43–44°C) and low solubility in water. The molecule features three fluorine atoms substituted at the 1, 3, and 5 positions of a benzene ring, contributing to its stability and unique chemical properties. It is commonly used as an intermediate in organic synthesis and has applications in various industrial processes.

What are the main uses of 1,3,5-Trifluorobenzene (CAS: 372-38-3)?

1,3,5-Trifluorobenzene (CAS: 372-38-3) is widely utilized in the pharmaceutical industry as a building block for drug development, particularly in creating fluorinated compounds with enhanced bioavailability. It also serves in agrochemicals, materials science, and research for producing fluorine-containing polymers and specialty chemicals. Additionally, it is used as a solvent in certain chemical processes and as a precursor for other trifluorinated aromatic derivatives.

Is 1,3,5-Trifluorobenzene (CAS: 372-38-3) safe?

1,3,5-Trifluorobenzene (CAS: 372-38-3) is generally considered low toxicity when handled properly, but it requires caution. Prolonged inhalation or skin contact may cause irritation, so safety measures like gloves, ventilation, and protective eyewear are recommended. It is classified as a hazardous substance under OSHA and EPA guidelines, necessitating adherence to safety standards to minimize exposure risks. Always follow proper handling protocols to ensure workplace safety.

How should 1,3,5-Trifluorobenzene (CAS: 372-38-3) be stored?

1,3,5-Trifluorobenzene (CAS: 372-38-3) should be stored in airtight, sealed containers in a cool (below 25°C), dry, and well-ventilated area. It is stable under normal conditions but sensitive to light, so storage in a dark place is essential. Avoid exposure to heat sources and maintain low humidity to prevent degradation. Always store it away from incompatible materials and ensure proper labeling for safe handling.