2-Chloronicotinaldehyde

Basic Information

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CAS Number

36404-88-3

Molecular Formula

C6H4ClNO

Molecular Weight

141.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

50-54 °C

Boiling Point

242.2℃ at 760 mmHg

Density

1.3320

Refractive Index

1.593

SMILES

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C1=CC(=C(N=C1)Cl)C=O

InChI

InChI=1S/C6H4ClNO/c7-6-5(4-9)2-1-3-8-6/h1-4H

InChIKey

KHPAGGHFIDLUMB-UHFFFAOYSA-N

LogP

1.5474999999999999

Topological Polar Surface Area

29.96 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

107

Safety Information

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GHS Hazard Pictograms

H302

H317

H319

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H317 May cause an allergic skin reaction
Sensitization, Skin

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

2-Chloro-pyridine-3-carbaldehyde
DTXSID40353269
HY-32791
PB27532
Chloro-2-formyl-3-pyridine
FT-0645301
2-chloro-3-pyridinecarbaldehyde
MFCD01315308
2-Chloropyridine-3-carbaldehyde
CS-W008584
AM20051116
3-PYRIDINECARBOXALDEHYDE, 2-CHLORO-
2-chloropyridine -3-carbaldehyde
2-chloro-3-pyridine carboxaldehyde
SY005203
BDBM92853
2-CHLORO-3-PYRIDINECARBOXYALDEHYDE
CHEMBL2228156
2-chloronicotinaldehyde
2-chloropyridine-3-carboxaldehyde
EN300-64170
2-Chloronicotinaldehyde, min.95%
BP-10103
2-Chloro-3-pyridinecarboxaldehyde
Nicotinamidase Inhibitor, 20
C2487
2-Chloro-3-formylpyridine
A6295
AC-1344
AKOS005070084
BCP08292

MDL Number

MFCD01315308

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Chloronicotinaldehyde (CAS: 36404-88-3)?

2-Chloronicotinaldehyde (CAS: 36404-88-3) is a crystalline compound with a molecular weight of approximately 161.58 g/mol. It has a melting point of 136-138°C and is slightly soluble in water. This compound is known for its reactivity towards nucleophiles and its ability to undergo condensation reactions.

How is 2-Chloronicotinaldehyde (CAS: 36404-88-3) typically synthesized?

2-Chloronicotinaldehyde is typically synthesized through the condensation of 2-chloronicotinamide with formaldehyde. The reaction usually involves the use of a strong base like sodium hydroxide or potassium hydroxide to enhance the nucleophilicity of the amide group, leading to a high yield of the desired product.

What industries use 2-Chloronicotinaldehyde (CAS: 36404-88-3)?

2-Chloronicotinaldehyde is utilized in various industries, including pharmaceuticals, where it is used as an intermediate in the synthesis of medicinal compounds. It also finds applications in the production of polymers, sensors, and semiconductors, due to its reactivity and functional groups.

What precautions should be taken when handling 2-Chloronicotinaldehyde (CAS: 36404-88-3)?

When handling 2-Chloronicotinaldehyde, it is important to wear personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. It should be stored in a closed container away from heat and ignition sources. Spills should be handled under a fume hood with appropriate cleanup procedures. Always refer to the Safety Data Sheet (SDS) for detailed safety information.