2-Chloronicotinaldehyde(CAS: 36404-88-3)

2-Chloronicotinaldehyde (CAS: 36404-88-3) is a crystalline compound with a molecular weight of approximately 161.58 g/mol. It has a melting point of 136-138°C and is slightly soluble in water. This compound is known for its reactivity towards nucleophiles and its ability to undergo condensation reactions.

2-Chloronicotinaldehyde is typically synthesized through the condensation of 2-chloronicotinamide with formaldehyde. The reaction usually involves the use of a strong base like sodium hydroxide or potassium hydroxide to enhance the nucleophilicity of the amide group, leading to a high yield of the desired product.

2-Chloronicotinaldehyde is utilized in various industries, including pharmaceuticals, where it is used as an intermediate in the synthesis of medicinal compounds. It also finds applications in the production of polymers, sensors, and semiconductors, due to its reactivity and functional groups.

When handling 2-Chloronicotinaldehyde, it is important to wear personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. It should be stored in a closed container away from heat and ignition sources. Spills should be handled under a fume hood with appropriate cleanup procedures. Always refer to the Safety Data Sheet (SDS) for detailed safety information.