Methyl 6-aminonicotinate

Basic Information

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CAS Number

36052-24-1

Molecular Formula

C7H8N2O2

Molecular Weight

152.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

158.0 to 162.0 deg-C

Boiling Point

304.5°C at 760 mmHg

Density

1.238

Flash Point

137.9℃

SMILES

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COC(=O)C1=CN=C(C=C1)N

InChI

InChI=1S/C7H8N2O2/c1-11-7(10)5-2-3-6(8)9-4-5/h2-4H,1H3,(H2,8,9)

InChIKey

JACPDLJUQLKABC-UHFFFAOYSA-N

LogP

0.4503999999999999

Topological Polar Surface Area

65.21000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

149

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

AQ-776/42801236
6-aminonicotinic acid methylester
Methy 6-aminonicotinate
6-Aminopyridine-3-carboxylic Acid Methyl Ester
12N-057
Methyl 6-amino-nicotinate
HMS2683A19
VU0323385-2
Oprea1_811931
2-Amino-5-methoxycarbonylpyridine
AC-9490
AKOS005069723
SY006453
M2107
Methyl 2-amino-5-pyridinecarboxylate
CS-W002681
JACPDLJUQLKABC-UHFFFAOYSA-N
6-Aminonicotinic acid methyl ester
6-aminonicotinic acid, methyl ester
CHEMBL1864652
DTXSID60353246
SMR000335157
W-200324
methyl 6-aminonicotinate
methyl 6-amino-pyridine-3-carboxylate
AM20070036
BB 0253960
EN300-139422
A6259
Z1117858114
6-amino-nicotinic acid methyl ester

MDL Number

MFCD00797844

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Methyl 6-aminonicotinate (CAS: 36052-24-1)?

Methyl 6-aminonicotinate (CAS: 36052-24-1) is a white crystalline solid with a molecular weight of approximately 191.21 g/mol. It is slightly soluble in water and ethanol. Chemically, it exhibits basic properties due to the presence of the amine group. It is moderately reactive and can undergo various chemical transformations, such as esterification and substitution reactions.

How is Methyl 6-aminonicotinate (CAS: 36052-24-1) typically synthesized?

Methyl 6-aminonicotinate is typically synthesized by the reaction of methyl 6-chloronicotinate with sodium hydride, followed by the addition of an amine. This process involves the displacement of the chloride group with an amine, yielding the desired product with high selectivity and good yield. The reaction is usually carried out in an inert solvent like dimethylformamide (DMF).

What industries use Methyl 6-aminonicotinate (CAS: 36052-24-1)?

Methyl 6-aminonicotinate (CAS: 36052-24-1) finds applications in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also used in the sensor industry due to its ability to act as a chromogenic reagent for detecting certain metal ions. Additionally, it can be utilized in the semiconductor industry for thin film applications.

What precautions should be taken when handling Methyl 6-aminonicotinate (CAS: 36052-24-1)?

When handling Methyl 6-aminonicotinate (CAS: 36052-24-1), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Proper spill cleanup procedures should be followed, and storage should be in a cool, dry place away from direct sunlight. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.