(3aR,6aS)-Tetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione

Basic Information

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CAS Number

35878-28-5

Molecular Formula

C7H8O3

Molecular Weight

140.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

73-74 ºC

Boiling Point

289.2°C at 760 mmHg

Flash Point

140.4°C

Refractive Index

1.555

SMILES

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C1CC2C(C1)C(=O)OC2=O

InChI

InChI=1S/C7H8O3/c8-6-4-2-1-3-5(4)7(9)10-6/h4-5H,1-3H2/t4-,5+

InChIKey

NMSRALOLNIBERV-SYDPRGILSA-N

LogP

0.48609999999999987

Topological Polar Surface Area

43.370000000000005 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

177

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

Synonyms & References

English

Rac-(3ar,6as)-hexahydro-1h-cyclopenta[c]furan-1,3-dione, cis
cis-1,2-Cyclopentanedicarboxylic anhydride
AKOS006277883
cis-Cyclopentane-1,2-dicarboxylic acid anhydride
(3aR,6aS)-4,5,6,6a-Tetrahydro-3aH-cyclopenta[c]furan-1,3-dione
cis-1,2-Cyclopentanedicarboxylicanhydride
cis-1,2-Cyclopentanedicarboxylic anhydride, >=97.0% (GC)
(3aS,6aR)-4,5,6,6a-tetrahydro-3aH-cyclopenta[c]furan-1,3-dione
NMSRALOLNIBERV-SYDPRGILSA-N
AT11428
35878-28-5
A823016
CS-0215478
EN300-252405
cis-Tetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione
FS-4035
cis-Tetrahydro-1H-cyclopenta(c)furan-1,3(4H)-dione
EINECS 252-773-0
(3aR,6aS)-hexahydro-1H-cyclopenta[c]furan-1,3-dione
cis-Cyclopentane-1,2-dicarboxylic anhydride
SCHEMBL4464324
1H-Cyclopenta[c]furan-1,3(3aH)-dione, tetrahydro-, (3aR,6aS)-rel-
MFCD01311171
1H-Cyclopenta[c]furan-1,3(3aH)-dione,tetrahydro-, (3aR,6aS)-rel-
CYCLOPENTANE-1,2-DICARBOXYLIC ACID ANHYDRIDE

MDL Number

MFCD01311171

Customs Code

2932999099

FAQ

What are the physical and chemical properties of (3aR,6aS)-Tetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione (CAS: 35878-28-5)?

(3aR,6aS)-Tetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione is a crystalline solid with a molecular weight of approximately 134.16 g/mol. It is poorly soluble in water but soluble in organic solvents such as ethanol and acetone. Chemically, it is relatively stable but reactive under acidic or basic conditions. It has a melting point of 165-167°C and a boiling point of 220-225°C.

How is (3aR,6aS)-Tetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione (CAS: 35878-28-5) typically synthesized?

(3aR,6aS)-Tetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione can be synthesized via the Wittig reaction or the Claisen condensation of appropriate precursors. The Wittig reaction involves the reaction of an aldehyde or ketone with a phosphonium ylide, while the Claisen condensation requires an ester and a phenol. The yield can be up to 80-90%, with good regioselectivity and stereoselectivity.

What industries use (3aR,6aS)-Tetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione (CAS: 35878-28-5)?

(3aR,6aS)-Tetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione is used in the pharmaceutical industry for the synthesis of bioactive compounds. It is also utilized in polymer research for developing new materials with specific properties. Additionally, it finds applications in the production of sensors and semiconductors due to its unique structural features.

What precautions should be taken when handling (3aR,6aS)-Tetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione (CAS: 35878-28-5)?

When handling (3aR,6aS)-Tetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione, protective gloves, safety goggles, and lab coats should be worn. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation. Spills should be cleaned up with appropriate absorbent materials, and the area should be thoroughly rinsed with water. Always refer to the Material Safety Data Sheet (MSDS) for detailed guidelines and emergency procedures.