2-Bromo-4-fluoropyridine

Basic Information

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CAS Number

357927-50-5

Molecular Formula

C5H3BrFN

Molecular Weight

175.99 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

188.791℃/760mmHg

Refractive Index

n20/D 1.537

SMILES

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C1=CN=C(C=C1F)Br

InChI

InChI=1S/C5H3BrFN/c6-5-3-4(7)1-2-8-5/h1-3H

InChIKey

AIEATTRZKVGMBO-UHFFFAOYSA-N

LogP

1.9832

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

78.8

Safety Information

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GHS Hazard Pictograms

H302

H318

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H318 Causes serious eye damage
Serious eye damage/eye irritation

Hazard Class

Class Comb liq. Class Comb liq.

Synonyms & References

English

SCHEMBL688866
2-Bromo-4-fluoropyridine, 96%
BCP26769
SY028281
AM20061850
AIEATTRZKVGMBO-UHFFFAOYSA-N
J-400251
PS-8595
AKOS005064104
EN300-94213
357927-50-5
HY-W003601
PYRIDINE, 2-BROMO-4-FLUORO-
AC-1906
B4760
CS-W003601
2-Bromo-4-fluoro-pyridine
MFCD09260909
AB50032
2-Bromo-4-fluoropyridine
FT-0647947
A6238
DTXSID70619446
PubChem3004
PYBR71
KSC493M3N
4-FLUORO-2-BROMOPYRIDINE
SBB089109
FCH836534
PC5846
AS04781

MDL Number

MFCD09260909

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Bromo-4-fluoropyridine (CAS: 357927-50-5)?

2-Bromo-4-fluoropyridine is a crystalline solid with a molecular weight of approximately 194.04 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetonitrile. Chemically, it is an electrophilic aromatic compound, showing reactivity towards nucleophiles under substitution conditions. It is used in the synthesis of pharmaceuticals and fine chemicals.

How is 2-Bromo-4-fluoropyridine (CAS: 357927-50-5) typically synthesized?

2-Bromo-4-fluoropyridine is typically synthesized through electrophilic aromatic substitution. A common method involves the bromination of 4-fluoropyridine using N-bromosuccinimide (NBS) and an appropriate radical initiator. The reaction is usually carried out in an organic solvent at room temperature, with high selectivity and good yield.

What industries use 2-Bromo-4-fluoropyridine (CAS: 357927-50-5)?

2-Bromo-4-fluoropyridine is primarily used in the pharmaceutical industry for the synthesis of drug intermediates and in the fine chemical industry for the production of various organic compounds. It is also utilized in the development of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 2-Bromo-4-fluoropyridine (CAS: 357927-50-5)?

When handling 2-Bromo-4-fluoropyridine, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be used in a well-ventilated area or a fume hood. Spills should be handled carefully, and appropriate spill cleanup procedures should be followed. Always consult the Safety Data Sheet (SDS) for detailed safety information.