2-Bromo-4-fluoropyridine(CAS: 357927-50-5)

2-Bromo-4-fluoropyridine is a crystalline solid with a molecular weight of approximately 194.04 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetonitrile. Chemically, it is an electrophilic aromatic compound, showing reactivity towards nucleophiles under substitution conditions. It is used in the synthesis of pharmaceuticals and fine chemicals.

2-Bromo-4-fluoropyridine is typically synthesized through electrophilic aromatic substitution. A common method involves the bromination of 4-fluoropyridine using N-bromosuccinimide (NBS) and an appropriate radical initiator. The reaction is usually carried out in an organic solvent at room temperature, with high selectivity and good yield.

2-Bromo-4-fluoropyridine is primarily used in the pharmaceutical industry for the synthesis of drug intermediates and in the fine chemical industry for the production of various organic compounds. It is also utilized in the development of sensors and semiconductors due to its unique chemical properties.

When handling 2-Bromo-4-fluoropyridine, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be used in a well-ventilated area or a fume hood. Spills should be handled carefully, and appropriate spill cleanup procedures should be followed. Always consult the Safety Data Sheet (SDS) for detailed safety information.