2,5-Difluorobenzoyl chloride

Basic Information

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CAS Number

35730-09-7

Molecular Formula

C7H3ClF2O

Molecular Weight

176.55 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

92-93 °C/34 mmHg

Refractive Index

n20/D 1.515(lit.)

SMILES

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C1=CC(=C(C=C1F)C(=O)Cl)F

InChI

InChI=1S/C7H3ClF2O/c8-7(11)5-3-4(9)1-2-6(5)10/h1-3H

InChIKey

RLRUKKDFNWXXRT-UHFFFAOYSA-N

LogP

2.3438

Topological Polar Surface Area

17.07 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

163

Safety Information

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Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Moisture Sensitive

Synonyms & References

English

7NDW4XJ5SK
EINECS 252-701-8
J-507338
Benzoyl chloride, 2,5-difluoro-
UNII-7NDW4XJ5SK
AM61486
2,5-difluoro-benzoyl chloride
35730-09-7
2,5-difluorobenzoylchloride
AKOS009156908
SCHEMBL343535
2,5-Difluorobenzoyl chloride
MFCD00009929
2-(chloromethyl)-1,4-difluoro-benzene
DTXSID10189274
JS-4111
A822960
2,5-Difluorobenzoyl chloride, 98%
FT-0601425
NS00057808
D3406
2,5-difluorobenzoyl chloride
C7H3ClF2O
2,4-DIFLUOROBENZOYLACETONITRILE
2,5-diflourobenzoyl chloride
2,5-diflurobenzoyl chloride
Benzoyl chloride,2,5-difluoro
difluorobenzoic acid chloride
2,5-Difluorobenzoylchloride
RLRUKKDFNWXXRT-UHFFFAOYSA-N
Benzoyl chloride,2,5-difluoro-

MDL Number

MFCD00009929

Customs Code

2916399090

FAQ

What are the physical and chemical properties of 2,5-Difluorobenzoyl chloride (CAS: 35730-09-7)?

2,5-Difluorobenzoyl chloride is a white crystalline solid with a molecular weight of approximately 214.6 g/mol. It is slightly soluble in water but soluble in organic solvents such as ethanol and dichloromethane. Chemically, it is highly reactive, particularly towards nucleophiles, and is often used in organic synthesis due to its electrophilic nature.

How is 2,5-Difluorobenzoyl chloride (CAS: 35730-09-7) typically synthesized?

2,5-Difluorobenzoyl chloride is typically synthesized by the chlorination of 2,5-difluorobenzoic acid in the presence of thionyl chloride. This process involves refluxing the mixture under anhydrous conditions to ensure high yield and selectivity. The reaction is carried out in a fume hood to manage the generation of toxic gases.

What industries use 2,5-Difluorobenzoyl chloride (CAS: 35730-09-7)?

2,5-Difluorobenzoyl chloride is widely used in the pharmaceutical industry for the synthesis of various drugs, particularly those requiring electrophilic functionality. It is also utilized in polymer science for functionalization of polymers and in the development of chemical sensors and semiconductors.

What precautions should be taken when handling 2,5-Difluorobenzoyl chloride (CAS: 35730-09-7)?

When handling 2,5-Difluorobenzoyl chloride, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize exposure to toxic gases. Spills should be handled carefully, and proper disposal should follow local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information.