Galanthamine | CAS No. 357-70-0

Galanthamine

Basic Information

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CAS Number

357-70-0

Molecular Formula

C17H21NO3

Molecular Weight

287.36 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Powder

Melting Point

119-1210C

Boiling Point

439.3°C at 760 mmHg

Solubility

Crystals from water; decomposition 256-257 °C. Sparingly sol in cold; more sol in hot water. Very sparingly sol in alcohol, acetone. /Hydrochloride/

Refractive Index

1.5022 (estimate)

Specific Rotation

D20 -118.8° (c = 1.378 in ethanol)

SMILES

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COc1ccc2CN(C)CC[C@]34C=C[C@H](O)C[C@@H]4Oc1c23

InChI

InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1

InChIKey

ASUTZQLVASHGKV-JDFRZJQESA-N

LogP

1.8502999999999998

Topological Polar Surface Area

41.93000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

440

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

Galanthamine base
(4as,6r,8as)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6h-benzofuro[3a,3,2-ef][2]benzazepin-6-ol
GALANTAMINE
GALANTHAMINE
GALANTHAMINE HYDROCHLORIDE
6H-Benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS-(4aalpha,6beta,8aR*))-
6h-benzofuro(3a,3,2-ef)(2)benzazepin-6-ol,4a,5,9,10,11,12-hexahydro-3-methox
Galantamin
Jilkon
Lycoremin
Lycoremine
y-11-methyl-
Galanthamine HBr CP2000
Galanthamine HCl
GalanthamineHydrobromideBase
FumalicAcid
Galantaminehydrochloride
(4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofurol[3a,3,2,-ef][2]benzazepin-6-ol
6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3 -methoxy-11-methyl-, (4aS,6R,8aS)-,
DANSHEN P.E.FOR INJECTION
GALANTHAMINE(P)
Galantamine Hydrobromide
(-)-Galanthamine
Razadyne
Galanthaminum
Nivalin
Razadyne ER
Galantaminum [INN-Latin]
Galantamina [INN-Spanish]
Galantamina
Reminyl (TN)

MDL Number

MFCD00867189

Customs Code

2942000000

FAQ

What is Galanthamine (CAS: 357-70-0)?

Galanthamine is a tertiary alkaloid derived from the bulbs of certain Galanthus species, such as snowdrops. It has the chemical formula C17H21NO4 and is known for its ability to inhibit acetylcholinesterase, making it a key compound in the treatment of Alzheimer's disease. It is a white crystalline solid with a bitter taste and is soluble in water and ethanol.

What are the main uses of Galanthamine (CAS: 357-70-0)?

Galanthamine is primarily used in pharmaceuticals as a cholinesterase inhibitor, particularly in the management of cognitive decline in Alzheimer's disease. It is also used in research for studying neurodegenerative conditions and in the development of drugs targeting acetylcholine pathways. Additionally, it has applications in the synthesis of other chemical compounds and as a natural product in botanical studies.

Is Galanthamine (CAS: 357-70-0) safe?

Galanthamine is generally considered safe when used as directed in medicinal applications. However, it should be handled with care, as high doses may lead to side effects such as nausea, dizziness, and gastrointestinal discomfort. Safety standards recommend proper storage and use under medical supervision to ensure its efficacy and minimize risks.

How should Galanthamine (CAS: 357-70-0) be stored?

Galanthamine should be stored in a cool, dry, and dark place, ideally at temperatures below 25°C. It is best kept in a sealed, airtight container to prevent moisture and contamination. Avoid exposure to light and maintain humidity levels below 60% to ensure its stability and prolong shelf life.