N-(Hydroxymethyl)nicotinamide

Basic Information

View in Editor

CAS Number

3569-99-1

Molecular Formula

C7H8N2O2

Molecular Weight

152.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

143.0 to 147.0 deg-C

Boiling Point

428

Density

1.262

Flash Point

213

Refractive Index

1.569

Vapor Pressure

0.0±1.1 mmHg at 25°C

SMILES

View in Editor

C1=CC(=CN=C1)C(=O)NCO

InChI

InChI=1S/C7H8N2O2/c10-5-9-7(11)6-2-1-3-8-4-6/h1-4,10H,5H2,(H,9,11)

InChIKey

JRFKIOFLCXKVOT-UHFFFAOYSA-N

LogP

-0.23880000000000012

Topological Polar Surface Area

62.22 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

138

Safety Information

View Safety Information

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

n-hydroxymethylnicotinamide
Spectrum5_001885
EN300-18232
KBio2_003424
C 1094
KBio3_001987
Savatin
Hydroxymethylnicotinamide
N-(Hydroxymethyl)nicotinamide
HYDROXYMETHYLNICOTINAMIDE [WHO-DD]
D90986
BRN 0128633
Nicodine
EINECS 222-668-4
Nicotinamide, N-(hydroxymethyl)-
NCGC00095786-02
SpecPlus_000641
Nicotinylmethylamide
N-(Hydroxymethyl)nicotinamide, 98%
Nicodin
N-(Hytroxymethy)micotinamide
KBioGR_001683
Nifoform
N-(hydroxymethyl)-nicotinamide
CHEMBL92024
Z57472937
Spectrum2_001197
NS00003038
DTXSID20189205
Isochol
N-(Hydroxymethyl)-3-pyridinecarboxamide

MDL Number

MFCD00010437

Customs Code

2933399090

FAQ

What are the physical and chemical properties of N-(Hydroxymethyl)nicotinamide (CAS: 3569-99-1)?

N-(Hydroxymethyl)nicotinamide is a white crystalline solid with a molecular weight of approximately 169.19 g/mol. It has a pKa of about 10.7 and is slightly soluble in water. The compound is stable under normal conditions but can react with strong acids to form nicotinic acid. It shows limited reactivity with bases and is not highly flammable.

How is N-(Hydroxymethyl)nicotinamide (CAS: 3569-99-1) typically synthesized?

N-(Hydroxymethyl)nicotinamide can be synthesized by the reaction of nicotinamide with formaldehyde in the presence of a base such as sodium hydroxide. The reaction is typically conducted in aqueous solution, and the product is isolated by precipitation and recrystallization. This method provides a high yield and good purity of the compound.

What industries use N-(Hydroxymethyl)nicotinamide (CAS: 3569-99-1)?

N-(Hydroxymethyl)nicotinamide is used in various industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of other compounds. It is also used in the production of polymers for specialized applications and in sensors for its ability to form complexes with metal ions. Additionally, it can be used in the semiconductor industry as a dopant.

What precautions should be taken when handling N-(Hydroxymethyl)nicotinamide (CAS: 3569-99-1)?

When handling N-(Hydroxymethyl)nicotinamide, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. It should be stored in a tightly sealed container in a cool, dry place away from incompatible substances. In the event of a spill, it should be contained and disposed of according to the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) guidelines.