N-(Hydroxymethyl)nicotinamide(CAS: 3569-99-1)

N-(Hydroxymethyl)nicotinamide is a white crystalline solid with a molecular weight of approximately 169.19 g/mol. It has a pKa of about 10.7 and is slightly soluble in water. The compound is stable under normal conditions but can react with strong acids to form nicotinic acid. It shows limited reactivity with bases and is not highly flammable.

N-(Hydroxymethyl)nicotinamide can be synthesized by the reaction of nicotinamide with formaldehyde in the presence of a base such as sodium hydroxide. The reaction is typically conducted in aqueous solution, and the product is isolated by precipitation and recrystallization. This method provides a high yield and good purity of the compound.

N-(Hydroxymethyl)nicotinamide is used in various industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of other compounds. It is also used in the production of polymers for specialized applications and in sensors for its ability to form complexes with metal ions. Additionally, it can be used in the semiconductor industry as a dopant.

When handling N-(Hydroxymethyl)nicotinamide, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. It should be stored in a tightly sealed container in a cool, dry place away from incompatible substances. In the event of a spill, it should be contained and disposed of according to the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) guidelines.