Fmoc-L-Leu-OH | CAS No. 35661-60-0

Fmoc-L-Leu-OH

Basic Information

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CAS Number

35661-60-0

Molecular Formula

C21H23NO4

Molecular Weight

353.42 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

152-156 °C <br />152-156 °C

Boiling Point

559.8°C at 760 mmHg

Flash Point

292.4 °C

Refractive Index

-25 ° (C=1, DMF)

Specific Rotation

-26 º (c=1,DMF 24 ºC)

SMILES

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CC(C)CC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

InChI

InChI=1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)/t19-/m0/s1

InChIKey

CBPJQFCAFFNICX-IBGZPJMESA-N

LogP

4.024400000000003

Topological Polar Surface Area

75.63 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

484

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

n-(fluorenyl-9-methoxycarbonyl)leucine
EINECS 252-662-7
NS00015081
Fmoc-L-Leu
Maybridge1_005562
CS-W019808
J-300159
N-(9-fluorenylmethoxycarbonyl)-L-leucine
CAS-35661-60-0
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine
N-(9-FLUORENYLMETHYLOXYCARBONYL)-LEUCINE
N-((9H-FLUOREN-9-YLMETHOXY)CARBONYL)-L-LEUCINE, (-)-
STR09711
Q27282223
Fmoc-L-leucine
N-(Fluoren-9-ylmethoxycarbonyl)-L-leucine
NCGC00164403-01
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-methylpentanoic acid
L-LEUCINE, N-((9H-FLUOREN-9-YLMETHOXY)CARBONYL)-
NSC-334290
BDBM115093
cid_1549133
35661-60-0
Tox21_301495
AKOS010398974
CHEMBL149394
DivK1c_001850
(2S)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-4-methylpentanoic acid
KF18F70UF3
AM20060470
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]leucine #

MDL Number

MFCD00037133

Customs Code

2924299090

FAQ

What is Fmoc-L-Leu-OH (CAS: 35661-60-0)?

Fmoc-L-Leu-OH, or N-(9-Fluorenylmethoxycarbonyl)-L-leucine hydrochloride, is a protected amino acid derivative commonly used in peptide synthesis. Its chemical formula is C25H25ClNO4, and it is characterized by a hydroxyl group on the leucine side chain. The compound is known for its stability and solubility in aqueous solutions, making it a valuable reagent in chemical research and pharmaceutical development.

What are the main uses of Fmoc-L-Leu-OH (CAS: 35661-60-0)?

Fmoc-L-Leu-OH is primarily used in the synthesis of peptides and proteins, particularly in solid-phase peptide synthesis (SPPS). It serves as a building block for creating complex molecules in drug development and biotechnology. Additionally, it is employed in research for studying amino acid functionality and in industrial applications for developing pharmaceutical compounds and bioactive materials.

Is Fmoc-L-Leu-OH (CAS: 35661-60-0) safe?

Fmoc-L-Leu-OH is generally considered safe when handled properly. However, it should be treated with caution as it may cause mild irritation if it comes into contact with skin or eyes. Protective equipment such as gloves and goggles is recommended. Safety standards for handling this compound are in line with standard laboratory practices for chemical reagents, ensuring minimal risk in controlled environments.

How should Fmoc-L-Leu-OH (CAS: 35661-60-0) be stored?

Fmoc-L-Leu-OH should be stored in a cool, dry place away from light. It is best kept in a sealed container at a temperature below 25°C and with humidity levels below 60%. Proper storage ensures the compound's stability and prevents degradation, maintaining its effectiveness for use in peptide synthesis and research applications.