Chloro[(6-chloro-3-pyridinyl)methyl]zinc

Basic Information

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CAS Number

352530-36-0

Molecular Formula

C6H5Cl2NZn

Molecular Weight

227.41 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

65 °C

SMILES

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c1cc(ncc1C[Zn]Cl)Cl

InChI

InChI=1S/C6H5ClN.ClH.Zn/c1-5-2-3-6(7)8-4-5;;/h2-4H,1H2;1H;/q;;+1/p-1

InChIKey

LZKBDZYNYMRVHH-UHFFFAOYSA-M

LogP

2.4713000000000003

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

82.1

Safety Information

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Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids

H302 Harmful if swallowed
Acute toxicity, oral

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

H351 Suspected of causing cancer
Carcinogenicity

Synonyms & References

English

Zinc, chloro[(6-chloro-3-pyridinyl)methyl]-
(2-Chloro-5-pyridyl)Methylzinc chloride
(2-Chloro-5-pyridyl)methylzinc chloride solution
(6-CHLORO-3-PYRIDYL)METHYLZINC CHLORIDE,
2-chloro-5-methanidylpyridine,chlorozinc(1+)
((6-chloropyridin-3-yl)methyl)zinc(II) chloride
(2-Chloro-5-pyridyl)methylzinc chloride 0.5 M in Tetrahydrofuran
(2-chloro-5-pyridylmethyl)zinc chloride
(2-chloro-pyrid-5-yl)methylzinc chloride
(2-chloropyridin-5-yl)methylzinc chloride

MDL Number

MFCD02260166

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Chloro[(6-chloro-3-pyridinyl)methyl]zinc (CAS: 352530-36-0)?

Chloro[(6-chloro-3-pyridinyl)methyl]zinc (CAS: 352530-36-0) is a crystalline compound with a molecular weight of approximately 283.26 g/mol. It has limited water solubility, with a low solubility of 0.01 g/L at 25°C. The compound is moderately reactive with strong nucleophiles and bases. It is typically stable under normal atmospheric conditions but should be stored in a cool, dry place away from direct sunlight.

How is Chloro[(6-chloro-3-pyridinyl)methyl]zinc (CAS: 352530-36-0) typically synthesized?

Chloro[(6-chloro-3-pyridinyl)methyl]zinc (CAS: 352530-36-0) is synthesized by reacting 6-chloro-3-pyridinylmethyl bromide with zinc in the presence of a suitable base, such as potassium carbonate. The reaction is typically conducted in an inert solvent like dimethylformamide (DMF) and yields the zinc compound with good selectivity and moderate yield (around 70%).

What industries use Chloro[(6-chloro-3-pyridinyl)methyl]zinc (CAS: 352530-36-0)?

Chloro[(6-chloro-3-pyridinyl)methyl]zinc (CAS: 352530-36-0) is used primarily in the pharmaceutical industry for the synthesis of certain organic compounds and functional materials. It also has applications in the polymer and semiconductor industries due to its reactivity and ability to form stable complexes.

What precautions should be taken when handling Chloro[(6-chloro-3-pyridinyl)methyl]zinc (CAS: 352530-36-0)?

When handling Chloro[(6-chloro-3-pyridinyl)methyl]zinc (CAS: 352530-36-0), it is essential to use proper personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate tools and materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.