1,3-Dimethyl-1H-pyrazol-5-amine

Basic Information

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CAS Number

3524-32-1

Molecular Formula

C5H9N3

Molecular Weight

111.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

65-69 °C

Boiling Point

234.7°C at 760 mmHg

Density

1.17

SMILES

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CC1=NN(C(=C1)N)C

InChI

InChI=1S/C5H9N3/c1-4-3-5(6)8(2)7-4/h3H,6H2,1-2H3

InChIKey

ZFDGMMZLXSFNFU-UHFFFAOYSA-N

LogP

0.31072

Topological Polar Surface Area

43.84 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

83.7

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

Hygroscopic

Synonyms & References

English

AM9899
86538-53-6
1H-PYRAZOL-5-AMINE, 1,3-DIMETHYL-
SCHEMBL266468
AKOS000263992
F2169-0755
3-amino-2,5-dimethyl-2h-pyrazole
5-amino-1,3-dimethyl-pyrazol
HMS3565I19
AB02131
5-Amino-1,3-dimethylpyrazole
1,3-dimethyl-1H-pyrazol-5-amine
5-amino-1,3-dimethyl pyrazole
A15517
Z55423092
AC-28105
BCP27524
1,3-DIMETHYL-5-AMINOPYRAZOLE
1,3-Dimethyl-1H-pyrazol-5-ylamine #
3-amino-2,5-dimethylpyrazole
SB36786
FT-0614904
3524-32-1
EN300-14984
1,3-dimethyl-5-pyrazolamine
5-amino-1,3-dimethyl-1h-pyrazole
1,3-dimethylpyrazol-5-amine
MFCD00051651
DTXSID30908181
1,3-dimethyl-1h-pyrazole-5-amine
5-Amino-1,3-dimethylpyrazole, 97%

MDL Number

MFCD00051651

Customs Code

2933199090

FAQ

What are the physical and chemical properties of 1,3-Dimethyl-1H-pyrazol-5-amine (CAS: 3524-32-1)?

1,3-Dimethyl-1H-pyrazol-5-amine (CAS: 3524-32-1) is a crystalline solid with a molecular weight of approximately 123.15 g/mol. It is slightly soluble in water and ethanol. Chemically, it is moderately reactive, particularly in acidic solutions where it can undergo deamination. It has a melting point of around 98-100°C and exhibits basic properties due to the amine group.

How is 1,3-Dimethyl-1H-pyrazol-5-amine (CAS: 3524-32-1) typically synthesized?

1,3-Dimethyl-1H-pyrazol-5-amine (CAS: 3524-32-1) can be synthesized via the Biginelli reaction, where 5-aminomethyl-3-methylpyrazole reacts with methyl acetoacetate in the presence of an acid catalyst such as sulfuric acid. The reaction is carried out at temperatures between 80-100°C, and the yield can be up to 90% depending on the purity of the starting materials.

What industries use 1,3-Dimethyl-1H-pyrazol-5-amine (CAS: 3524-32-1)?

1,3-Dimethyl-1H-pyrazol-5-amine (CAS: 3524-32-1) is primarily used in the pharmaceutical industry for the synthesis of various drugs. It is also utilized in the polymer industry for the production of special polymers and in the sensor industry for detecting specific gases. Additionally, it finds applications in the semiconductor industry for certain fabrication processes.

What precautions should be taken when handling 1,3-Dimethyl-1H-pyrazol-5-amine (CAS: 3524-32-1)?

When handling 1,3-Dimethyl-1H-pyrazol-5-amine (CAS: 3524-32-1), wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or under a fume hood. In case of spill, neutralize any acidic residues with a base before cleaning up. Refer to the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.