4-Fluoro-2-hydroxybenzaldehyde

Basic Information

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CAS Number

348-28-7

Molecular Formula

C7H5FO2

Molecular Weight

140.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

70-72°C

Boiling Point

208.2℃ at 760 mmHg

SMILES

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C1=CC(=C(C=C1F)O)C=O

InChI

InChI=1S/C7H5FO2/c8-6-2-1-5(4-9)7(10)3-6/h1-4,10H

InChIKey

GBJJCODOZGPTBC-UHFFFAOYSA-N

LogP

1.3437999999999999

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

127

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

Air Sensitive

Synonyms & References

English

2-hydroxy-4-fluorobenzaldehyde
CS-W008001
4-fluoro-2-hydroxy-benzaldehyde
4-fluoro-2-hydroxybenzaldehyde
GBJJCODOZGPTBC-UHFFFAOYSA-N
J-515431
Z1201622454
4-Fluor-2-hydroxy-benzaldehyd
2-Hydroxy-4-fluoro-benzaldehyde
4-fluoro-2-hydroxy benzaldehyde
FT-0631997
DTXSID90381355
4-Fluorosalicylaldehyde
AKOS005257139
SB23032
AC-1973
A6113
EN300-97011
MFCD03788526
AM20050105
348-28-7
SY030946
SCHEMBL172942
CL8352
PS-9052
2-HYDROXY-4-FLUOROBENZALDEHYDE
4-Fluoro-2-hydroxybenzaldehyde
4-fluorosalicylaldehyde (4-fluoro-2-hydroxybenzaldehyde)
PubChem8483
KSC497M4P
BEN211

MDL Number

MFCD03788526

Customs Code

2913000090

FAQ

What are the physical and chemical properties of 4-Fluoro-2-hydroxybenzaldehyde (CAS: 348-28-7)?

4-Fluoro-2-hydroxybenzaldehyde is a white crystalline solid with a molecular weight of 165.05 g/mol. It is slightly soluble in water and soluble in ethanol and other organic solvents. It exhibits moderate reactivity, particularly towards nucleophilic and electrophilic reactions. The compound has a pKa of approximately 10.2 and can act as a weak acid.

How is 4-Fluoro-2-hydroxybenzaldehyde (CAS: 348-28-7) typically synthesized?

4-Fluoro-2-hydroxybenzaldehyde can be synthesized via the reduction of 4-fluoro-2-hydroxybenzaldehyde-2-oxide, or by the alkylation of 4-fluoro-2-hydroxybenzoic acid. Commonly, the synthesis involves the use of sodium borohydride as a reducing agent and is carried out in a polar aprotic solvent such as dimethyl sulfoxide (DMSO). The yield is generally around 85-90%, with high selectivity to the desired product.

What industries use 4-Fluoro-2-hydroxybenzaldehyde (CAS: 348-28-7)?

4-Fluoro-2-hydroxybenzaldehyde is utilized in the pharmaceutical industry for the synthesis of certain drugs, particularly those requiring aromatic scaffolds. It is also used in the polymer industry for the modification of polymer properties and in the sensor industry for the development of chemical sensors. Additionally, it has applications in semiconductor manufacturing for specific etching processes.

What precautions should be taken when handling 4-Fluoro-2-hydroxybenzaldehyde (CAS: 348-28-7)?

When handling 4-Fluoro-2-hydroxybenzaldehyde, it is important to wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and a lab coat. This compound should be used in a well-ventilated area or in a fume hood to minimize exposure. Spills should be cleaned up using absorbent materials and the area should be thoroughly rinsed. Handling this compound requires adherence to safety data sheet (SDS) guidelines and storage should be in a cool, dry place away from direct sunlight and heat sources.