Compound Q&A

How is 4-Fluoro-2-hydroxybenzaldehyde (CAS: 348-28-7) typically synthesized?

Answer

4-Fluoro-2-hydroxybenzaldehyde
4-Fluoro-2-hydroxybenzaldehyde can be synthesized via the reduction of 4-fluoro-2-hydroxybenzaldehyde-2-oxide, or by the alkylation of 4-fluoro-2-hydroxybenzoic acid. Commonly, the synthesis involves the use of sodium borohydride as a reducing agent and is carried out in a polar aprotic solvent such as dimethyl sulfoxide (DMSO). The yield is generally around 85-90%, with high selectivity to the desired product.

About

CAS No 348-28-7
English Name 4-Fluoro-2-hydroxybenzaldehyde
Molecular Formula C7H5FO2
Molecular Weight 140.11 g/mol
SMILES C1=CC(=C(C=C1F)O)C=O
InChIKey GBJJCODOZGPTBC-UHFFFAOYSA-N
Last Updated: 2025-10-01 13:51

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