4-Fluoro-2-hydroxybenzaldehyde(CAS: 348-28-7)

4-Fluoro-2-hydroxybenzaldehyde is a white crystalline solid with a molecular weight of 165.05 g/mol. It is slightly soluble in water and soluble in ethanol and other organic solvents. It exhibits moderate reactivity, particularly towards nucleophilic and electrophilic reactions. The compound has a pKa of approximately 10.2 and can act as a weak acid.

4-Fluoro-2-hydroxybenzaldehyde can be synthesized via the reduction of 4-fluoro-2-hydroxybenzaldehyde-2-oxide, or by the alkylation of 4-fluoro-2-hydroxybenzoic acid. Commonly, the synthesis involves the use of sodium borohydride as a reducing agent and is carried out in a polar aprotic solvent such as dimethyl sulfoxide (DMSO). The yield is generally around 85-90%, with high selectivity to the desired product.

4-Fluoro-2-hydroxybenzaldehyde is utilized in the pharmaceutical industry for the synthesis of certain drugs, particularly those requiring aromatic scaffolds. It is also used in the polymer industry for the modification of polymer properties and in the sensor industry for the development of chemical sensors. Additionally, it has applications in semiconductor manufacturing for specific etching processes.

When handling 4-Fluoro-2-hydroxybenzaldehyde, it is important to wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and a lab coat. This compound should be used in a well-ventilated area or in a fume hood to minimize exposure. Spills should be cleaned up using absorbent materials and the area should be thoroughly rinsed. Handling this compound requires adherence to safety data sheet (SDS) guidelines and storage should be in a cool, dry place away from direct sunlight and heat sources.