2-(4-Fluorophenyl)imidazo[1,2-a]pyridine

Basic Information

View in Editor

CAS Number

347-12-6

Molecular Formula

C13H9FN2

Molecular Weight

212.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

View in Editor

Fc1ccc(cc1)c2cn3ccccc3n2

InChI

InChI=1S/C13H9FN2/c14-11-6-4-10(5-7-11)12-9-16-8-2-1-3-13(16)15-12/h1-9H

InChIKey

PNOFVTHZVLYOFR-UHFFFAOYSA-N

LogP

3.1404000000000014

Topological Polar Surface Area

17.3 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Synonyms & References

English

2-(4-Fluorophenyl)imidazo[1,2-a]pyridine
Imidazo[1,2-a]pyridine, 2-(4-fluorophenyl)-
2-(4-fluorophenyl)imidazo1,2-apyridine

MDL Number

MFCD00269178

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 2-(4-Fluorophenyl)imidazo[1,2-a]pyridine (CAS: 347-12-6)?

2-(4-Fluorophenyl)imidazo[1,2-a]pyridine is a crystalline solid with a molecular weight of approximately 233.15 g/mol. It has a solubility of about 0.3 g/L in water and is poorly soluble in organic solvents. Chemically, it is relatively stable but can undergo mild hydrolysis under alkaline conditions. It is a weak base with a pKa of around 8.5.

How is 2-(4-Fluorophenyl)imidazo[1,2-a]pyridine (CAS: 347-12-6) typically synthesized?

2-(4-Fluorophenyl)imidazo[1,2-a]pyridine is synthesized through a multi-step process involving the reaction of 4-fluorophenyl isocyanate with imidazol-2-amine. The reaction is carried out in an inert atmosphere using anhydrous solvents like toluene, and the product is isolated by column chromatography. Yields are typically around 70-80%, and the method is selective for the desired product.

What industries use 2-(4-Fluorophenyl)imidazo[1,2-a]pyridine (CAS: 347-12-6)?

2-(4-Fluorophenyl)imidazo[1,2-a]pyridine is primarily used in the pharmaceutical industry as an intermediate for the synthesis of drug candidates. It also finds applications in the polymer industry for the development of novel materials and in the semiconductor industry for use in organic electronics and sensors.

What precautions should be taken when handling 2-(4-Fluorophenyl)imidazo[1,2-a]pyridine (CAS: 347-12-6)?

When handling 2-(4-Fluorophenyl)imidazo[1,2-a]pyridine, it is essential to wear appropriate protective equipment such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. In case of skin contact, rinse with water immediately. Ingestion should be avoided, and if swallowed, seek medical attention immediately. The material safety data sheet (MSDS) should always be consulted for detailed safety information.