2-(4-Fluorophenyl)imidazo[1,2-a]pyridine(CAS: 347-12-6)

2-(4-Fluorophenyl)imidazo[1,2-a]pyridine is a crystalline solid with a molecular weight of approximately 233.15 g/mol. It has a solubility of about 0.3 g/L in water and is poorly soluble in organic solvents. Chemically, it is relatively stable but can undergo mild hydrolysis under alkaline conditions. It is a weak base with a pKa of around 8.5.

2-(4-Fluorophenyl)imidazo[1,2-a]pyridine is synthesized through a multi-step process involving the reaction of 4-fluorophenyl isocyanate with imidazol-2-amine. The reaction is carried out in an inert atmosphere using anhydrous solvents like toluene, and the product is isolated by column chromatography. Yields are typically around 70-80%, and the method is selective for the desired product.

2-(4-Fluorophenyl)imidazo[1,2-a]pyridine is primarily used in the pharmaceutical industry as an intermediate for the synthesis of drug candidates. It also finds applications in the polymer industry for the development of novel materials and in the semiconductor industry for use in organic electronics and sensors.

When handling 2-(4-Fluorophenyl)imidazo[1,2-a]pyridine, it is essential to wear appropriate protective equipment such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. In case of skin contact, rinse with water immediately. Ingestion should be avoided, and if swallowed, seek medical attention immediately. The material safety data sheet (MSDS) should always be consulted for detailed safety information.