2-Chloro-3-fluoro-5-methylpyridine

Basic Information

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CAS Number

34552-15-3

Molecular Formula

C6H5ClFN

Molecular Weight

145.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

92°C/25mmHg

Density

1.264

Flash Point

65.2℃

Refractive Index

1.504

SMILES

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CC1=CC(=C(N=C1)Cl)F

InChI

InChI=1S/C6H5ClFN/c1-4-2-5(8)6(7)9-3-4/h2-3H,1H3

InChIKey

XZJURWKNRAGMCG-UHFFFAOYSA-N

LogP

2.1825200000000002

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

99.1

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

MFCD06658238
CS-D0946
2-chloro-3-fluoro-5-picoline
BCP22120
PS-6415
AKOS005063651
2-Chloro-3-fluoro-5-methyl-pyridine;2-Chloro-3-fluoro-5-methylpyridine
2-Chloro-3-fluoro-5-methyl pyridine
6-chloro-5-fluoro-3-methylpyridine
C3275
EN300-82814
AC-24936
6-Chloro-5-fluoro-3-picoline
DTXSID80543283
J-508649
Pyridine, 2-chloro-3-fluoro-5-methyl-
SCHEMBL17892
AM20061733
XZJURWKNRAGMCG-UHFFFAOYSA-N
2-Chloro-3-fluoro-5-methyl-pyridine
2-chloro-3-fluoro-5-methylpyridine
A6076
FT-0602432
34552-15-3
SY018331
2-Chloro-3-fluoro-5-methylpyridine
2-Chloro-3-fluoro-5-picoline
2-fluoro-3-Chloro-5-methylpyridine
2-Chlor-3-fluor-5-methylpyridin
PubChem14231
KSC495Q2T

MDL Number

MFCD06658238

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Chloro-3-fluoro-5-methylpyridine (CAS: 34552-15-3)?

2-Chloro-3-fluoro-5-methylpyridine is a crystalline solid with a molecular weight of approximately 165.58 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. The compound is relatively stable but can react with strong bases and reducing agents. It has a melting point of about 52-54°C and a boiling point of 188-190°C. It is a key intermediate in the synthesis of various pharmaceuticals and agrochemicals.

How is 2-Chloro-3-fluoro-5-methylpyridine (CAS: 34552-15-3) typically synthesized?

2-Chloro-3-fluoro-5-methylpyridine is commonly synthesized via the Friedel-Crafts alkylation of 3-chloro-5-methylpyridine with methyl chloride in the presence of aluminum chloride as a catalyst. This process yields a high selectivity and good yield. The reaction is typically carried out at around 80-90°C under anhydrous conditions to achieve the desired product.

What industries use 2-Chloro-3-fluoro-5-methylpyridine (CAS: 34552-15-3)?

2-Chloro-3-fluoro-5-methylpyridine is used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs, particularly those targeting viral infections. It is also utilized in the agrochemical sector for the production of herbicides. Additionally, it has applications in the formulation of sensors and as a precursor in the development of some high-performance polymers.

What precautions should be taken when handling 2-Chloro-3-fluoro-5-methylpyridine (CAS: 34552-15-3)?

When handling 2-Chloro-3-fluoro-5-methylpyridine, it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents, and the area should be flushed with water. Refer to the safety data sheet (SDS) for specific handling and disposal instructions. Ensure good ventilation and avoid contact with skin and eyes.