2-Chloro-3-fluoro-5-methylpyridine(CAS: 34552-15-3)

2-Chloro-3-fluoro-5-methylpyridine is a crystalline solid with a molecular weight of approximately 165.58 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. The compound is relatively stable but can react with strong bases and reducing agents. It has a melting point of about 52-54°C and a boiling point of 188-190°C. It is a key intermediate in the synthesis of various pharmaceuticals and agrochemicals.

2-Chloro-3-fluoro-5-methylpyridine is commonly synthesized via the Friedel-Crafts alkylation of 3-chloro-5-methylpyridine with methyl chloride in the presence of aluminum chloride as a catalyst. This process yields a high selectivity and good yield. The reaction is typically carried out at around 80-90°C under anhydrous conditions to achieve the desired product.

2-Chloro-3-fluoro-5-methylpyridine is used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs, particularly those targeting viral infections. It is also utilized in the agrochemical sector for the production of herbicides. Additionally, it has applications in the formulation of sensors and as a precursor in the development of some high-performance polymers.

When handling 2-Chloro-3-fluoro-5-methylpyridine, it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents, and the area should be flushed with water. Refer to the safety data sheet (SDS) for specific handling and disposal instructions. Ensure good ventilation and avoid contact with skin and eyes.