2-Amino-N-(2-bromophenyl)benzamide

Basic Information

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CAS Number

34489-85-5

Molecular Formula

C13H11BrN2O

Molecular Weight

291.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Powder

SMILES

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C1=CC=C(C(=C1)C(=O)NC2=CC=CC=C2Br)N

InChI

InChI=1S/C13H11BrN2O/c14-10-6-2-4-8-12(10)16-13(17)9-5-1-3-7-11(9)15/h1-8H,15H2,(H,16,17)

InChIKey

KNSXPWPBPXHJHV-UHFFFAOYSA-N

LogP

3.2836000000000007

Topological Polar Surface Area

55.120000000000005 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

272

Synonyms & References

English

A822254
F75318
AKOS000126431
DTXSID10588142
AMY27061
34489-85-5
2-AMINO-N-(2-BROMOPHENYL)BENZAMIDE
FT-0713190
2-azanyl-N-(2-bromophenyl)benzamide
AG-F-18045
AGN-PC-015R03
anthranilic acid-(2-bromo-anilide)
Anthranilsaeure-
Anthranilsaeure-(2-brom-anilid)
Benzamide,2-amino-N-(2-bromophenyl)-
Benzanilide,2-amino-2'-bromo- (7CI)
CTK4H2487

MDL Number

MFCD08443320

Customs Code

2924299090

FAQ

What are the physical and chemical properties of 2-Amino-N-(2-bromophenyl)benzamide (CAS: 34489-85-5)?

2-Amino-N-(2-bromophenyl)benzamide (CAS: 34489-85-5) is a crystalline compound with a molecular weight of approximately 324.02 g/mol. It has a low solubility in water but is more soluble in organic solvents like DMSO and DMF. The compound exhibits basic properties due to its amine group and reactive towards electrophiles, particularly in amide and amino functionalities.

How is 2-Amino-N-(2-bromophenyl)benzamide (CAS: 34489-85-5) typically synthesized?

2-Amino-N-(2-bromophenyl)benzamide (CAS: 34489-85-5) is commonly synthesized via nucleophilic substitution of a bromobenzene derivative with an anilide, followed by amidation under basic conditions. The reaction typically involves a condensation step using a condensing agent like HOBt and a base like DIPEA, with a yield of around 70-80%.

What industries use 2-Amino-N-(2-bromophenyl)benzamide (CAS: 34489-85-5)?

2-Amino-N-(2-bromophenyl)benzamide (CAS: 34489-85-5) is primarily used in the pharmaceutical industry as an intermediate in drug synthesis. It also finds applications in polymer chemistry, where its properties are utilized in the development of functional materials, and in sensor technology due to its reactivity and chemical stability.

What precautions should be taken when handling 2-Amino-N-(2-bromophenyl)benzamide (CAS: 34489-85-5)?

When handling 2-Amino-N-(2-bromophenyl)benzamide (CAS: 34489-85-5), it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Handle in a fume hood to avoid inhalation. Ensure proper ventilation and avoid skin contact. In case of a spill, neutralize with an appropriate solution and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety instructions.