(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid

Basic Information

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CAS Number

3398-22-9

Molecular Formula

C5H9NO3

Molecular Weight

131.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

261 °C (dec)

Boiling Point

355.2°C at 760 mmHg

Density

1.395

Flash Point

168.6℃

Refractive Index

1.54

SMILES

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C1C(CNC1C(=O)O)O

InChI

InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m0/s1

InChIKey

PMMYEEVYMWASQN-IUYQGCFVSA-N

LogP

-0.87740

Complexity

125

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Sensitization, respiratory

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AKOS006349670
CS-0020162
D-Hyp-OH
trans-4-Hydroxy-D-proline, 97%
D-4-Hydroxyproline
rac-(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid
4-(S)-hydroxypyrrolidine-2-(R)-carboxylic acid
(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid
CHEBI:27992
PMMYEEVYMWASQN-IUYQGCFVSA-N
J-019406
DS-14000
A13216
3398-22-9
(2R,4S)-4-Hydroxy-pyrrolidine-2-carboxylic acid
(2R,4S)-4-hydroxypyrrolidin-1-ium-2-carboxylate
SCHEMBL200243
AKOS015855303
P17905
C03651
trans-4-Hydroxy-D-proline
d-hydroxyproline
H-D-Hyp-OH
D-Proline, 4-hydroxy-,(4S)-
Q-102876
UY7
EN300-7039450
MFCD00065608
trans-4-Hydroxy-D-proline (H-D-Hyp-OH)
InChI=1/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m0/s
(4S)-4-hydroxy-D-proline

MDL Number

MFCD03414107

Customs Code

2933990090

FAQ

What regulatory guidelines apply to (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 3398-22-9)?

Regulatory guidelines for (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 3398-22-9) include GHS classification, which categorizes it as a skin irritant. It is also subject to REACH regulations in the EU, requiring suppliers to register the substance if produced or imported in quantities above 1 ton per year. Additionally, FDA and EPA have specific requirements for its handling and disposal to ensure environmental safety and compliance with U.S. regulations.

Are there alternatives to (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 3398-22-9) in synthesis?

In the synthesis of (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 3398-22-9), several alternatives can be used. For instance, (2R,4R)- and (2S,4S)-isomers can serve as viable alternatives. Common alternative reagents include amino acids like proline, which can be modified to achieve similar structural properties. Utilizing these alternatives can help in achieving the desired product with better efficiency and safety.

What is the market or research trend for (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 3398-22-9)?

The market and research trends for (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 3398-22-9) are increasingly focused on its applications in pharmaceuticals and as a chiral building block in synthetic chemistry. Recent research trends highlight its use in developing new drug candidates and in the production of advanced materials. Market studies predict steady growth due to its high demand in these sectors, with ongoing exploration into its potential for use in biotechnology and nanotechnology.

How should waste containing (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 3398-22-9) be handled?

Waste containing (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 3398-22-9) should be collected in appropriate containers and disposed of through professional waste disposal services. Incineration is a common method for disposal, ensuring complete destruction of the compound. Environmental protection precautions include minimizing the release of waste into the environment and adhering to local and international environmental regulations to prevent contamination. Proper training and safety measures are essential to ensure the safe handling and disposal of this substance.