Noroxymorphone

Basic Information

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CAS Number

33522-95-1

Molecular Formula

C16H17NO4

Molecular Weight

287.32 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

>265°C (dec.)

Flash Point

22℃

SMILES

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C1CC2(C3CC4=C5C2(CCN3)C(C1=O)OC5=C(C=C4)O)O

InChI

InChI=1S/C16H17NO4/c18-9-2-1-8-7-11-16(20)4-3-10(19)14-15(16,5-6-17-11)12(8)13(9)21-14/h1-2,11,14,17-18,20H,3-7H2/t11-,14+,15+,16-/m1/s1

InChIKey

HLMSIZPQBSYUNL-IPOQPSJVSA-N

LogP

0.4029999999999999

Topological Polar Surface Area

78.79 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

511

Synonyms & References

English

Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-, (5alpha)- (9CI)
(4R,4aS,7aR,12bS)-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one
(5.alpha.)-4,5-epoxy-3,14-dihydroxymorphinan-6-one
9NZ7111A9O
NOROXYMORPHONE [USP IMPURITY]
4,5alpha-Epoxy-3,14-dihydroxy morphinan-6-one
(-)-Noroxymorphone
Nor Oxymorphone (1.0mg/ml in DMSO)
Noroxymorphone
NOROXYMORPHONE [WHO-DD]
SCHEMBL136548
NS00015493
NALOXONE HYDROCHLORIDE DIHYDRATE IMPURITY A [EP IMPURITY]
Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-, (5alpha)-
DTXSID80955145
33522-95-1
7,8-Dihydro-14-hydroxynormorphinone
CHEBI:187724
Nor Oxymorphone
14-Hydroxydihydronormorphinone
EN-3169
EN 3169
Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-, (5.alpha.)-
(4R,4aS,7aR,12bS)-4a,9-dihydroxy-1,2,3,4,5,6,7a,13-octahydro-4,12-methanobenzouro[3,2-e]isoquinolin-7-one
HLMSIZPQBSYUNL-IPOQPSJVSA-N
Morphinan-6-one, 4,5alpha-epoxy-3,14-dihydroxy- (8CI)
(5alpha)-4,5-Epoxy-3,14-dihydroxymorphinan-6-one
Q25102255
UNII-9NZ7111A9O
EINECS 251-561-5
(5α)-4,5-epoxy-3,14-dihydroxymorphinan-6-one

MDL Number

MFCD00058530

FAQ

What are the physical and chemical properties of Noroxymorphone (CAS: 33522-95-1)?

Noroxymorphone is a white or off-white crystalline powder with a molecular weight of 344.39 g/mol. It is slightly soluble in water and alcohol. The compound is stable under normal storage conditions but can degrade upon prolonged exposure to heat and light. It is a potent opioid analgesic with a high affinity for the μ-opioid receptor.

How is Noroxymorphone (CAS: 33522-95-1) typically synthesized?

Noroxymorphone is synthesized through a series of chemical reactions, including the reduction of oxymorphone to noroxymorphone. Common methods involve the use of hydrogenation catalysts such as palladium on carbon. The reaction typically yields a high purity product, though careful monitoring of reaction conditions is necessary to achieve the desired selectivity and yield.

What industries use Noroxymorphone (CAS: 33522-95-1)?

Noroxymorphone is primarily used in the pharmaceutical industry due to its analgesic properties. It is also of interest in academic research for studying opioid receptor function. While not commonly used in other industries like polymers or semiconductors, its unique chemical properties make it a subject of study in sensor technology.

What precautions should be taken when handling Noroxymorphone (CAS: 33522-95-1)?

When handling Noroxymorphone, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always consult the Material Safety Data Sheet (MSDS/SDS) for detailed information on handling and storage.