2-Amino-5-fluorobenzenethiol

Basic Information

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CAS Number

33264-82-3

Molecular Formula

C6H6FNS

Molecular Weight

143.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

186 ºC

Boiling Point

240 ºC

Flash Point

99 ºC

Refractive Index

1.63

SMILES

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Nc1ccc(F)cc1S

InChI

InChI=1S/C6H6FNS/c7-4-1-2-5(8)6(9)3-4/h1-3,9H,8H2

InChIKey

UPEWNVDJDYMWIV-UHFFFAOYSA-N

LogP

1.6965999999999999

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

99.1

Synonyms & References

English

2-amino-5-fluorothiophenol
2-Amino-5-fluorobenzenethiol
Benzenethiol, 2-amino-5-fluoro-
2-amino-5-fluorobenzene-1-thiol
2-amino-5-fluoro-benzenethiol
2-mercapto-4-fluoroaniline
4-fluoro-2-mercapto-aniline
5-fluoro-2-aminobenzenethiol
Benzenethiol,2-amino-5-fluoro
(4-Fluoro-2-mercaptophenyl)amine
4-Fluoro-2-mercaptoaniline
NSC 268651

MDL Number

MFCD09909740

Customs Code

2930909090

FAQ

What are the physical and chemical properties of 2-Amino-5-fluorobenzenethiol (CAS: 33264-82-3)?

2-Amino-5-fluorobenzenethiol (CAS: 33264-82-3) is a white crystalline solid with a molecular weight of approximately 179.04 g/mol. It is sparingly soluble in water but more soluble in organic solvents like ethanol and acetone. This compound is known for its reactivity, particularly towards electrophilic aromatic substitution reactions.

How is 2-Amino-5-fluorobenzenethiol (CAS: 33264-82-3) typically synthesized?

2-Amino-5-fluorobenzenethiol is typically synthesized through a multi-step process involving the fluorination of benzenethiol, followed by alkylation or acylation to introduce the amino group. Common catalysts include Lewis acids, and the reaction often requires the use of organic solvents at elevated temperatures.

What industries use 2-Amino-5-fluorobenzenethiol (CAS: 33264-82-3)?

2-Amino-5-fluorobenzenethiol (CAS: 33264-82-3) is used in various industries, including pharmaceuticals for drug synthesis, polymer science for functional monomers, and chemical sensing for the development of advanced sensors and semiconductors.

What precautions should be taken when handling 2-Amino-5-fluorobenzenethiol (CAS: 33264-82-3)?

When handling 2-Amino-5-fluorobenzenethiol (CAS: 33264-82-3), proper personal protective equipment (PPE) should be worn, including gloves, goggles, and lab coats. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed safety instructions.