2-Chloroisonicotinonitrile

Basic Information

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CAS Number

33252-30-1

Molecular Formula

C6H3ClN2

Molecular Weight

138.55 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

70.0 to 74.0 deg-C

Boiling Point

106°C/15mmHg

Density

1.3300

Flash Point

104-106°C/15mm

Refractive Index

1.565?

SMILES

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C1=CN=C(C=C1C#N)Cl

InChI

InChI=1S/C6H3ClN2/c7-6-3-5(4-8)1-2-9-6/h1-3H

InChIKey

QRXBTPFMCTXCRD-UHFFFAOYSA-N

LogP

1.60668

Complexity

137

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

NS00124777
CL0075
2-chloro-4-pyridinenitrile
BCP22779
2-Chloroisonicotinonitrile
Pyridine, 2-chloro-, 4-cyano-
2-Chloro-4-pyridinecarbonitrile
4-Pyridinecarbonitrile, 2-chloro-
C1873
2-Chloropyridine-4-carbonitrile
AB04394
2-chloro-4 pyridinecarbonitrile
AC-907/30003049
33252-30-1
2-Chloro-4-pyridinecarbonitrile, 97%
1Y-0715
2-Chloro-isonicotinonitrile
MFCD00174318
AM20061867
2-chloropyridine -4-carbonitrile
F2158-0490
AKOS005070056
FT-0611958
AC-226
2-chloro-4-cyano-pyridine
EN300-26966
4-cyano-2-chloropyridin
U2S8C7U4ER
BCP9000101
2-chloro-4-cyano pyridine
UNII-U2S8C7U4ER

MDL Number

MFCD00174318

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Chloroisonicotinonitrile (CAS: 33252-30-1)?

2-Chloroisonicotinonitrile (CAS: 33252-30-1) is a crystalline solid with a molecular weight of approximately 149.02 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetonitrile. This compound is chemically reactive, particularly towards nucleophilic substitution reactions. It is used in the synthesis of pharmaceuticals and other organic compounds.

How is 2-Chloroisonicotinonitrile (CAS: 33252-30-1) typically synthesized?

2-Chloroisonicotinonitrile (CAS: 33252-30-1) is typically synthesized by the electrophilic aromatic substitution of nicotinonitrile with chlorine in the presence of a Lewis acid catalyst, such as aluminum chloride. The reaction provides good selectivity and yield, making it a common method in organic synthesis.

What industries use 2-Chloroisonicotinonitrile (CAS: 33252-30-1)?

2-Chloroisonicotinonitrile (CAS: 33252-30-1) is primarily used in the pharmaceutical industry for the synthesis of various drugs. It is also utilized in the chemical industry for the preparation of other organic compounds, particularly those involving nitrile or chlorine functionalities.

What precautions should be taken when handling 2-Chloroisonicotinonitrile (CAS: 33252-30-1)?

When handling 2-Chloroisonicotinonitrile (CAS: 33252-30-1), it is important to use appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. The material should be handled in a well-ventilated area or a fume hood to reduce exposure. Spills should be cleaned up using appropriate chemical spill kits, and the Material Safety Data Sheet (MSDS) should be consulted for detailed safety information.