2-Chloroisonicotinonitrile(CAS: 33252-30-1)

2-Chloroisonicotinonitrile (CAS: 33252-30-1) is a crystalline solid with a molecular weight of approximately 149.02 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetonitrile. This compound is chemically reactive, particularly towards nucleophilic substitution reactions. It is used in the synthesis of pharmaceuticals and other organic compounds.

2-Chloroisonicotinonitrile (CAS: 33252-30-1) is typically synthesized by the electrophilic aromatic substitution of nicotinonitrile with chlorine in the presence of a Lewis acid catalyst, such as aluminum chloride. The reaction provides good selectivity and yield, making it a common method in organic synthesis.

2-Chloroisonicotinonitrile (CAS: 33252-30-1) is primarily used in the pharmaceutical industry for the synthesis of various drugs. It is also utilized in the chemical industry for the preparation of other organic compounds, particularly those involving nitrile or chlorine functionalities.

When handling 2-Chloroisonicotinonitrile (CAS: 33252-30-1), it is important to use appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. The material should be handled in a well-ventilated area or a fume hood to reduce exposure. Spills should be cleaned up using appropriate chemical spill kits, and the Material Safety Data Sheet (MSDS) should be consulted for detailed safety information.