Ethyl 2-chloro-3-oxopropanoate

Basic Information

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CAS Number

33142-21-1

Molecular Formula

C5H7ClO3

Molecular Weight

150.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Physical State

White to Yellow Solid

Flash Point

65℃

SMILES

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O=C(OCC)C(Cl)C=O

InChI

InChI=1S/C5H7ClO3/c1-2-9-5(8)4(6)3-7/h3-4H,2H2,1H3

InChIKey

DWXKSCKBUSAOKS-UHFFFAOYSA-N

LogP

0.3557999999999999

Topological Polar Surface Area

43.370000000000005 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Stability

Store FROZEN

Synonyms & References

English

ethyl (chloroformyl)acetate
Ethyl 2-Chloro-3-oxopropanoate
ETHYL 2-CHLORO-2-FORMYLACETATE
Propanoic acid, 2-chloro-3-oxo-, ethyl ester
2-Chloro-3-oxopropanoic acid ethyl ester
2-chloro-3-oxo-propionic acid ethyl ester
A-chloroacetate
A-Formyl-
chlorocarboethoxyacetaldehyde
Ethyl
ethyl 2-chloro-3-oxo-propionate
ethyl 2-formyl-2-chloro-acetate
ethyl formylchloroacetate
ethyl 2-chloro-3-oxo-propanoate

MDL Number

MFCD07369378

Customs Code

2918300090

FAQ

What are the physical and chemical properties of Ethyl 2-chloro-3-oxopropanoate (CAS: 33142-21-1)?

Ethyl 2-chloro-3-oxopropanoate is a crystalline solid with a molecular weight of approximately 147.58 g/mol. It has a melting point of 65-67°C and is slightly soluble in water. It is reactive towards nucleophiles and can undergo hydrolysis. This compound is also susceptible to acid-catalyzed cleavage to form ethyl acetate and chloroform.

How is Ethyl 2-chloro-3-oxopropanoate (CAS: 33142-21-1) typically synthesized?

Ethyl 2-chloro-3-oxopropanoate is commonly synthesized via the reaction of ethyl chloroacetate with sodium hydroxide. The process involves the hydrolysis of ethyl chloroacetate to form ethyl 2-chloro-3-oxopropanoate, with good selectivity and yield. This method requires careful control of pH and temperature to ensure the desired product is formed.

What industries use Ethyl 2-chloro-3-oxopropanoate (CAS: 33142-21-1)?

Ethyl 2-chloro-3-oxopropanoate is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also utilized in polymer production, where it can be incorporated into polymer chains to modify their properties. Additionally, it has applications in sensor technology and semiconductor manufacturing due to its reactivity and specific functional groups.

What precautions should be taken when handling Ethyl 2-chloro-3-oxopropanoate (CAS: 33142-21-1)?

When handling Ethyl 2-chloro-3-oxopropanoate, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure to the compound. Handle with care to avoid skin contact and inhalation. In case of spills, neutralize with an appropriate base and dispose of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed information on handling and disposal.