Ethyl 2-chloro-3-oxopropanoate(CAS: 33142-21-1)

Ethyl 2-chloro-3-oxopropanoate is a crystalline solid with a molecular weight of approximately 147.58 g/mol. It has a melting point of 65-67°C and is slightly soluble in water. It is reactive towards nucleophiles and can undergo hydrolysis. This compound is also susceptible to acid-catalyzed cleavage to form ethyl acetate and chloroform.

Ethyl 2-chloro-3-oxopropanoate is commonly synthesized via the reaction of ethyl chloroacetate with sodium hydroxide. The process involves the hydrolysis of ethyl chloroacetate to form ethyl 2-chloro-3-oxopropanoate, with good selectivity and yield. This method requires careful control of pH and temperature to ensure the desired product is formed.

Ethyl 2-chloro-3-oxopropanoate is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also utilized in polymer production, where it can be incorporated into polymer chains to modify their properties. Additionally, it has applications in sensor technology and semiconductor manufacturing due to its reactivity and specific functional groups.

When handling Ethyl 2-chloro-3-oxopropanoate, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure to the compound. Handle with care to avoid skin contact and inhalation. In case of spills, neutralize with an appropriate base and dispose of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed information on handling and disposal.