Phenylmethanesulfonyl fluoride

Basic Information

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CAS Number

329-98-6

Molecular Formula

C7H7FO2S

Molecular Weight

174.2 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

92.0 to 95.0 deg-C

Boiling Point

85°C/0.3mmHg

Solubility

dry solvents (ethanol, methanol, and 2-propanol): 200 mM Stock solution are stable for months at 4°C.

Refractive Index

1.502

SMILES

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FS(=O)(=O)Cc1ccccc1

InChI

InChI=1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2

InChIKey

YBYRMVIVWMBXKQ-UHFFFAOYSA-N

LogP

1.4859000000000002

Topological Polar Surface Area

34.14 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

199

Safety Information

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GHS Hazard Pictograms

H301

H314

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Moisture Sensitive

Toxicity

LD50 (24 hr) in mice (mg/kg): 215 ±55 i.p. (Pinsky)

Synonyms & References

English

4-METHYLBENZENESULFONYL FLUORIDE
4-TOLUENESULFONYL FLUORIDE
4-TOLUENESULPHONYL FLUORIDE
ALPHA-TOLUENESULPHONYL FLUORIDE
A-TOLUENESULFONYL FLUORIDE
A-TOLUENESULPHONYL FLUORIDE
PHENYLMETHANESULFONIC ACID FLUORIDE
PHENYLMETHANESULPHONYL FLUORIDE
PHENYLMETHANSULFOFLUORIDE
PHENYLMETHYLSUFONYL FLUORIDE
PHENYLMETHYLSULPHONYL FLUORIDE
PMSF
PMSF PLUS
P-TOLUENESULFONYL FLUORIDE
P-TOLUENESULPHONYL FLUORIDE
Phenylmethanesulfonyl fluoride (PMSF)
Benzylsulfonyl Fluoride [for Biochemical Research]
PHENYLMETHYLSULFONYL FLUORIDE (PMSF)
Benzylsulphonyl fluoride
phenylmethyl-sulfonyl fluoride
phenylmethylsulfonyl fluoride
a-Toluenesulfonyl fluoride(7CI,8CI)
Benzylsulfonyl fluoride
NSC 88499
Phenylmethanesulfonylfluoride
alpha-Toluenesulfonyl fluoride
Benzenemethanesulfonyl fluoride
Phenylmethanesulfonyl fluoride
Phenylmethylsulfonyl fluoride
Phenylmethylsulfonyl Fluoride

MDL Number

MFCD00007424

Customs Code

2904909090

FAQ

What is Phenylmethanesulfonyl fluoride (CAS: 329-98-6)?

Phenylmethanesulfonyl fluoride (PMSF), with the CAS number 329-98-6, is an organic compound commonly used as a serine protease inhibitor. It has the chemical formula C8H9FO2S and appears as a white crystalline solid. PMSF is known for its reactivity and ability to inhibit enzymes by forming covalent bonds with the active site's serine residue.

What are the main uses of Phenylmethanesulfonyl fluoride (CAS: 329-98-6)?

Phenylmethanesulfonyl fluoride (PMSF) is widely used in pharmaceutical research, biochemistry, and protein analysis. It serves as a tool to study enzyme activity and is applied in drug development, particularly in the inhibition of proteolytic enzymes. PMSF is also used in the purification of proteins and in the synthesis of various organic compounds.

Is Phenylmethanesulfonyl fluoride (CAS: 329-98-6) safe?

Phenylmethanesulfonyl fluoride (PMSF) is considered toxic and should be handled with care. It can cause irritation to the skin, eyes, and respiratory system, and may be harmful if ingested. Safety protocols include using personal protective equipment (PPE) and working in a well-ventilated area. It is not recommended for use in food or consumer products due to its chemical nature.

How should Phenylmethanesulfonyl fluoride (CAS: 329-98-6) be stored?

Phenylmethanesulfonyl fluoride (PMSF) should be stored in a cool, dry, and dark place, ideally at temperatures below 25°C. It is sensitive to moisture and light, so it must be kept in a sealed, airtight container. Proper storage ensures stability and prevents degradation of the compound's activity.