2,6-dimethoxypyrimidin-4-amine

Basic Information

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CAS Number

3289-50-7

Molecular Formula

C6H9N3O2

Molecular Weight

155.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

149.0 to 153.0 deg-C

Boiling Point

340.1 ºC at 760 mmHg

Density

1.229

Flash Point

159.5 ºC

Solubility

methanol: soluble25mg/mL, clear, colorless to yellow

Refractive Index

1.547

SMILES

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COC1=NC(=NC(=C1)N)OC

InChI

InChI=1S/C6H9N3O2/c1-10-5-3-4(7)8-6(9-5)11-2/h3H,1-2H3,(H2,7,8,9)

InChIKey

LNTJJKHTAZFVJJ-UHFFFAOYSA-N

LogP

0.0759999999999999

Topological Polar Surface Area

70.26 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

122

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

Pyrimidine,6-dimethoxy-
4-Pyrimidinamine, 2,6-dimethoxy-
NSC-166290
Z1255486563
3289-50-7
AB03140
Sulfadimethoxine EP Impurity A
2,6-Dimethoxy-4-aminopyrimidine
6-Amino-2,4-dimethoxypyrimidine
O10630
LSF4SEX5LP
W-106808
4-Amino-2,6-dimethoxypyrimidine, 97%
NSC 166290
2,6-Dimethoxy-pyrimidin-4-ylamine
TS-00075
NS00029376
2,6-Dimethoxypyrimidin-4-amine
MFCD00082802
Pyrimidine, 4-amino-2,6-dimethoxy-
A5880
SULFADIMETHOXINE IMPURITY A [EP IMPURITY]
DTXSID2062959
SCHEMBL504020
2,6-Dimethoxy-4-pyrimidinamine
(2,6-DIMETHOXYPYRIMIDIN-4-YL)AMINE
SULFADIMETHOXINE SODIUM FOR VETERINARY USE IMPURITY A [EP IMPURITY]
4-amino-2,6-dimethoxypyrimidin
SY021279
CS-W018020
4-Pyrimidinamine,6-dimethoxy-

MDL Number

MFCD00082802

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 2,6-dimethoxypyrimidin-4-amine (CAS: 3289-50-7)?

2,6-Dimethoxypyrimidin-4-amine (CAS: 3289-50-7) has a crystalline form with a molecular weight of approximately 198.17 g/mol. It is sparingly soluble in water but soluble in common organic solvents like ethanol and dichloromethane. The compound is moderately reactive and can undergo nucleophilic substitution reactions. It is stable under normal laboratory conditions but should be stored away from direct sunlight and heat sources.

How is 2,6-dimethoxypyrimidin-4-amine (CAS: 3289-50-7) typically synthesized?

2,6-Dimethoxypyrimidin-4-amine (CAS: 3289-50-7) is typically synthesized via a multistep process involving the reaction of 2,6-dimethoxypyridine with hydrazine hydrate. The synthesis involves mild heating and typically uses hydrazine hydrate as the primary reagent. The yield is generally good, around 70-80%, and the reaction is known to be selective under these conditions.

What industries use 2,6-dimethoxypyrimidin-4-amine (CAS: 3289-50-7)?

2,6-Dimethoxypyrimidin-4-amine (CAS: 3289-50-7) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various pyrimidine-based drugs. It also has applications in the polymer industry for the development of advanced materials and as a functional group in organic synthesis for the preparation of other heterocyclic compounds.

What precautions should be taken when handling 2,6-dimethoxypyrimidin-4-amine (CAS: 3289-50-7)?

When handling 2,6-dimethoxypyrimidin-4-amine (CAS: 3289-50-7), it is important to wear appropriate Personal Protective Equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials and the area should be flushed with water. It is advisable to refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.