Fmoc-D-Aph(Cbm)-OH

Basic Information

View in Editor

CAS Number

324017-22-3

Molecular Formula

C25H23N3O5

Molecular Weight

445.48 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Solubility

Insuluble (3.5E-3 g/L) (25 ºC),

SMILES

View in Editor

C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CC4=CC=C(C=C4)NC(=O)N)C(=O)O

InChI

InChI=1S/C25H23N3O5/c26-24(31)27-16-11-9-15(10-12-16)13-22(23(29)30)28-25(32)33-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14H2,(H,28,32)(H,29,30)(H3,26,27,31)/t22-/m1/s1

InChIKey

HFPDOFBZCSQAEJ-JOCHJYFZSA-N

LogP

3.7116000000000025

Topological Polar Surface Area

130.75 Å²

Hydrogen Bond Donor/Acceptor

5 / 8

Complexity

686

Synonyms & References

English

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-ureidophenyl)propanoic acid
(2R)-3-[4-(carbamoylamino)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
4-[(AMinocarbonyl)aMino]-N-[(9H-fluoren-9-ylMethoxy)carbonyl]-D-phenylalanine
Fmoc-d-aph(cbm)-oh
M4G8FC9DUL
Fmoc-D-Aph(Cbm)-OH
AKOS022173563
4-[(Aminocarbonyl)amino]-N-Fmoc-D-phenylalanine
SCHEMBL23421399
324017-22-3
(2r)-3-(4-(carbamoylamino)phenyl)-2-(9h-fluoren-9-ylmethoxycarbonylamino)propanoic acid
W11485
D-Phenylalanine, 4-[(aminocarbonyl)amino]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
(2R)-3-[4-(CARBAMOYLAMINO)PHENYL]-2-{[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO}PROPANOIC ACID
(2R)-3-[4-(carbamoylamino)phenyl]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
(2R)-3-[4-(carbamoylamino)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic Acid
AMY22822
MolPort-035-677-459
AS-73471
MFCD26743751
CS-0037288
DTXSID30444216

MDL Number

MFCD26743751

FAQ

What are the physical and chemical properties of Fmoc-D-Aph(Cbm)-OH (CAS: 324017-22-3)?

Fmoc-D-Aph(Cbm)-OH (CAS: 324017-22-3) is a crystalline compound with a molecular weight of approximately 539.4 g/mol. It has a low solubility in water but is soluble in organic solvents such as DMF and DMSO. The compound is known for its reactivity in coupling reactions, particularly in solid-phase peptide synthesis.

How is Fmoc-D-Aph(Cbm)-OH (CAS: 324017-22-3) typically synthesized?

Fmoc-D-Aph(Cbm)-OH is synthesized via a multi-step process involving the coupling of D-Aph(Cbm) with Fmoc-Cl under anhydrous conditions. The reaction typically requires a coupling reagent such as HOBt and a base like triethylamine. The yield is usually around 70-80%, with high selectivity for the desired product.

What industries use Fmoc-D-Aph(Cbm)-OH (CAS: 324017-22-3)?

Fmoc-D-Aph(Cbm)-OH (CAS: 324017-22-3) is primarily used in the pharmaceutical industry for the synthesis of peptides and proteins. It is also utilized in the polymer industry for functionalization and in the sensor industry for biosensing applications.

What precautions should be taken when handling Fmoc-D-Aph(Cbm)-OH (CAS: 324017-22-3)?

When handling Fmoc-D-Aph(Cbm)-OH (CAS: 324017-22-3), ensure the use of appropriate personal protective equipment (PPE), such as gloves, lab coat, and safety goggles. Handle the compound under a fume hood due to its reactivity. In case of a spill, immediately clean it up using appropriate absorbents and follow the safety data sheet (SDS) guidelines for disposal.