2-Methyl 1-(2-methyl-2-propanyl) (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate

Basic Information

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CAS Number

321744-26-7

Molecular Formula

C12H21NO5

Molecular Weight

259.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

402.56°C (rough estimate)

Refractive Index

1.4596 (estimate)

SMILES

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CC(C)(C)OC(=O)N1CCC(CC1C(=O)OC)O

InChI

InChI=1S/C12H21NO5/c1-12(2,3)18-11(16)13-6-5-8(14)7-9(13)10(15)17-4/h8-9,14H,5-7H2,1-4H3/t8-,9+/m0/s1

InChIKey

RNMVWSAJMIKMDY-DTWKUNHWSA-N

LogP

0.9197999999999995

Topological Polar Surface Area

76.07000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 6

Complexity

323

Synonyms & References

English

SCHEMBL584834
DTXSID10370342
(2R,4S)-N-Boc-4-Hydroxypiperidine-2-Carboxylic Acid Methyl Ester
1-tert-butyl 2-methyl (2R,4S)-4-hydroxypiperidine-1,2-dicarboxylate
Methyl (2R,4S)-1-boc-4-hydroxypiperidine-2-carboxylate
(2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypiperidine-1,2-dicarboxylate
CS-W000270
BS-49184
AC-35177
P18951
1-TERT-BUTYL 2-METHYL CIS-4-HYDROXYPIPERIDINE-1,2-DICARBOXYLATE
(2R,4S)-N-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylic acid methyl ester
(2R,4S)-1-tert-Butyl2-methyl4-hydroxypiperidine-1,2-dicarboxylate
WLZ3847
AMY25456
1-O-tert-butyl 2-O-methyl (2R,4S)-4-hydroxypiperidine-1,2-dicarboxylate
1,2-Piperidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4S)-rel-
RNMVWSAJMIKMDY-DTWKUNHWSA-N
CIS-4-HYDROXY-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER
n-tert-butoxycarbonyl-cis-4-hydroxy-l-pipecolinic acid methyl ester
(2R,4S)-4-Hydroxy-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester
AKOS005256941
1-t-Butyl 2-methyl (2R,4S)-4-hydroxypiperidine-1,2-dicarboxylate
321744-26-7
A821184
MFCD02259744
WMA74426
(2R,4S)-N-BOC-4-Hydroxypiperidine-2-carboxylic acid methyl ester
1,2-Piperidinedicarboxylicacid, 4-hydroxy-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4S)-
N-Boc-4-hydroxy-2-piperidine carboxylic acid methyl ester
PIP039

MDL Number

MFCD02259744

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Methyl 1-(2-methyl-2-propanyl) (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate (CAS: 321744-26-7)?

2-Methyl 1-(2-methyl-2-propanyl) (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate (CAS: 321744-26-7) is a crystalline solid with a molecular weight of approximately 336.4 g/mol. It has a low solubility in water but is soluble in common organic solvents like ethanol and acetone. The compound is moderately reactive, particularly toward nucleophiles and bases. It is stable under normal conditions but should be stored in a cool, dry place to prevent hydrolysis.

How is 2-Methyl 1-(2-methyl-2-propanyl) (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate (CAS: 321744-26-7) typically synthesized?

2-Methyl 1-(2-methyl-2-propanyl) (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate (CAS: 321744-26-7) can be synthesized via a multistep process involving the reaction of 2-methyl-2-propanol and 1,2-piperidinedicarboxylic acid. The synthesis typically uses a mild base like sodium hydroxide to facilitate the esterification reaction. High selectivity and good yield are achieved under optimal conditions.

What industries use 2-Methyl 1-(2-methyl-2-propanyl) (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate (CAS: 321744-26-7)?

2-Methyl 1-(2-methyl-2-propanyl) (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate (CAS: 321744-26-7) is primarily used in pharmaceuticals for the synthesis of active pharmaceutical ingredients. It is also utilized in the production of polymers and in sensor applications due to its unique chemical properties. Its use in semiconductors is less common but is explored for its electronic properties.

What precautions should be taken when handling 2-Methyl 1-(2-methyl-2-propanyl) (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate (CAS: 321744-26-7)?

When handling 2-Methyl 1-(2-methyl-2-propanyl) (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate (CAS: 321744-26-7), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood. In case of spill, it should be cleaned up carefully with appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.