5-Fluoro-2-pyridinecarbaldehyde

Basic Information

View in Editor

CAS Number

31181-88-1

Molecular Formula

C6H4FNO

Molecular Weight

125.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

174 ºC

Density

1.269

Flash Point

59 ºC

SMILES

View in Editor

C1=CC(=NC=C1F)C=O

InChI

InChI=1S/C6H4FNO/c7-5-1-2-6(4-9)8-3-5/h1-4H

InChIKey

IACCXWQKIQUVFQ-UHFFFAOYSA-N

LogP

1.0332

pKa

1.30±0.10(Predicted)

Topological Polar Surface Area

29.96 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

107

Safety Information

View Safety Information

Hazard Statement

Storage Conditions

under inert gas (nitrogen or Argon) at 2-8°C

Synonyms & References

English

J-517555
AMY7949
Z1201624239
5-Fluoro-pyridine-2-carbaldehyde
MFCD07781242
FT-0659239
5-fluoropyridine-2-carbaldehyde
31181-88-1
SY015686
CS-W004870
AC-33349
5-fluoropicolinaldehyde
DTXSID50438450
5-fluro-2-formylpyridine
BCP10413
SCHEMBL108007
BP-13350
IACCXWQKIQUVFQ-UHFFFAOYSA-N
5-FLUOROPYRIDINE-2-CARBOXALDEHYDE
AB42648
5-fluoro-2-formylpyridine, AldrichCPR
AKOS006343736
PS-9207
EN300-136115
J-018270
2-PYRIDINECARBOXALDEHYDE, 5-FLUORO-
5-Fluoro-2-formylpyridine
5-FLUORO-2-PYRIDINE CARBOXALDEHYDE
2-Pyridinecarboxaldehyde,5-fluoro
5-Fluoropicolinaldehyde
2-BROMO-3-FLUOROPYRIDINE

MDL Number

MFCD07781242

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 5-Fluoro-2-pyridinecarbaldehyde (CAS: 31181-88-1)?

5-Fluoro-2-pyridinecarbaldehyde (CAS: 31181-88-1) is a white crystalline solid with a molecular weight of 148.06 g/mol. It has a low solubility in water (0.2 g/L at 20°C) but is more soluble in organic solvents like ethanol and acetone. It is reactive towards nucleophiles and can undergo condensation reactions. This compound is often used in organic synthesis and pharmaceuticals.

How is 5-Fluoro-2-pyridinecarbaldehyde (CAS: 31181-88-1) typically synthesized?

5-Fluoro-2-pyridinecarbaldehyde (CAS: 31181-88-1) can be synthesized from 2-pyridinecarbaldehyde using fluoroform (CHF3) in the presence of a base like potassium tert-butoxide. The reaction is typically carried out in anhydrous conditions to minimize side reactions, ensuring high selectivity and good yield.

What industries use 5-Fluoro-2-pyridinecarbaldehyde (CAS: 31181-88-1)?

5-Fluoro-2-pyridinecarbaldehyde (CAS: 31181-88-1) is primarily used in the pharmaceutical industry for the synthesis of various drug candidates. It also finds applications in the polymer industry for the development of new materials and in the sensor technology sector for creating chemical sensors.

What precautions should be taken when handling 5-Fluoro-2-pyridinecarbaldehyde (CAS: 31181-88-1)?

When handling 5-Fluoro-2-pyridinecarbaldehyde (CAS: 31181-88-1), it is important to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be stored in a cool, dry place away from direct sunlight. Spills should be cleaned up using appropriate absorbent materials and the area should be ventilated. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.