Compound Q&A

How is 5-Fluoro-2-pyridinecarbaldehyde (CAS: 31181-88-1) typically synthesized?

Answer

5-Fluoro-2-pyridinecarbaldehyde
5-Fluoro-2-pyridinecarbaldehyde (CAS: 31181-88-1) can be synthesized from 2-pyridinecarbaldehyde using fluoroform (CHF3) in the presence of a base like potassium tert-butoxide. The reaction is typically carried out in anhydrous conditions to minimize side reactions, ensuring high selectivity and good yield.

About

CAS No 31181-88-1
English Name 5-Fluoro-2-pyridinecarbaldehyde
Molecular Formula C6H4FNO
Molecular Weight 125.1 g/mol
SMILES C1=CC(=NC=C1F)C=O
InChIKey IACCXWQKIQUVFQ-UHFFFAOYSA-N
Last Updated: 2025-10-16 16:48

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