3'-Azido-3'-deoxythymidine

Basic Information

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CAS Number

30516-87-1

Molecular Formula

C10H13N5O4

Molecular Weight

267.24 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Powder

Melting Point

113-115 °C

Boiling Point

410.43°C (rough estimate)

Water Solubility

1-5 g/100 mL at 17 ºC

Flash Point

9℃

Solubility

H2O: 50 mg/mL

Refractive Index

47 ° (C=1, H2O)

Vapor Pressure

No data available

Specific Rotation

+50° ~ +60° (C=1, EtOH)

SMILES

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CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-]

InChI

InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

InChIKey

HBOMLICNUCNMMY-XLPZGREQSA-N

LogP

log Kow = 0.05

Complexity

484

Safety Information

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GHS Hazard Pictograms

H351

Hazard Statement

H351 Suspected of causing cancer
Carcinogenicity

Hazard Class

Class 6.1 Class 6.1

Sensitiveness

Light Sensitive & Hygroscopic

Toxicity

LD50 in male, female mice, male, female rats (mg/kg): 3568, 3062, 3084, 3683 orally; >750 i.v. (all species) (Ayers)

Synonyms & References

English

ZIDOVUDINE (MART.)
Z754931264
Propolis & Thymidine, 3'-azido-3'-deoxy-
DS-4152 & AZT
AZT & rsCD4 & rIFN.alpha.A
CCRIS 105
Timazid
KBio3_002653
4B9XT59T7S
racemic-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
Spectrum2_000927
AZT & SST
Zidovudine; 1-(3-Azido-2,3-dideoxy-?-d-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione; Zidovudine (GR 63367X); BP Zidovudine and Lamivudine Impurity Standard
3'-Azido-3'-deoxythymidine & Lithium & Erythropoietin
Retrovir(TM)
NCGC00178237-02
Zidovudine [USAN:USP:INN:BAN:JAN]
ZIDOVUDINE [JAN]
NCGC00023945-03
IDI1_000524
DRG-0004
UNII-4B9XT59T7S
AKOS005622576
Zidovudine, United States Pharmacopeia (USP) Reference Standard
3'-Azido-3'-deoxythymidine & Concanavalin A
ZIDOVUDINE [INN]
BDBM50002692
Liposomal AZT-SN-3
1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione (N3ddThd)
1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione (AZT)
AZT, Antiviral

MDL Number

MFCD00386763

Customs Code

2933990090

FAQ

What is 3'-Azido-3'-deoxythymidine (CAS: 30516-87-1)?

3'-Azido-3'-deoxythymidine, also known as AZT, is an antiretroviral compound used in the treatment of HIV. Its chemical formula is C14H14N4O3. It is a white crystalline solid that is soluble in water and has a molecular weight of 266.29 g/mol. This compound is a nucleoside analog that inhibits the enzyme reverse transcriptase, which is essential for HIV replication.

What are the main uses of 3'-Azido-3'-deoxythymidine (CAS: 30516-87-1)?

3'-Azido-3'-deoxythymidine (AZT) is primarily used in pharmaceuticals as an antiretroviral drug for managing HIV infections. It is also employed in research for studying antiviral mechanisms and in the development of new therapeutic agents. Additionally, it has applications in molecular biology for nucleic acid synthesis and as a tool in drug discovery processes.

Is 3'-Azido-3'-deoxythymidine (CAS: 30516-87-1) safe?

3'-Azido-3'-deoxythymidine (AZT) is generally considered safe when used as prescribed in medical treatment, but it can have side effects such as bone marrow suppression and liver toxicity. Proper handling and adherence to safety guidelines are essential. It is classified as a Schedule II controlled substance in some regions due to its potential for abuse and the need for strict regulatory control.

How should 3'-Azido-3'-deoxythymidine (CAS: 30516-87-1) be stored?

3'-Azido-3'-deoxythymidine (AZT) should be stored in a cool, dry place away from direct light. It is typically kept in airtight containers to prevent moisture absorption. Stability is maintained under these conditions, and it is important to store it properly to ensure its efficacy and safety. Always follow manufacturer guidelines for specific storage requirements.