2-Bromo-1,3-thiazole

Basic Information

View in Editor

CAS Number

3034-53-5

Molecular Formula

C3H2BrNS

Molecular Weight

164.03 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Water Treatment Chemicals Disinfectants Chlorine Compounds

Basic Physical Properties

Melting Point

171 C

Boiling Point

171 °C

Refractive Index

n20/D 1.593(lit.)

SMILES

View in Editor

C1=CSC(=N1)Br

InChI

InChI=1S/C3H2BrNS/c4-3-5-1-2-6-3/h1-2H

InChIKey

RXNZFHIEDZEUQM-UHFFFAOYSA-N

LogP

1.9056000000000002

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

50.1

Safety Information

View Safety Information

GHS Hazard Pictograms

H227

Hazard Statement

H227 Combustible liquid
Flammable liquids

Hazard Class

Class IRRITANT Class IRRITANT

Class FLAMMABLE Class FLAMMABLE

Sensitiveness

Sensitive to heat and air

Synonyms & References

English

Thiazole, 2-bromo-
BP-20653
bromothiazole
2- bromothiazole
NSC 91532
2-bromo thiazole
2-bromo-thiazole
CS-W001223
2-Bromo-1,3-thiazole
2-bromothiazol
2-Bromothiazole
STR03615
AB00399
SY001649
NSC-91532
NS00047795
3034-53-5
FT-0611616
53KY5HU6FR
2-Bromo-thiazole;2-bromo-1,3-thiazole;2-Thiazolyl Bromide;Thiazole, 2-bromo-
AM803661
Q-100385
UNII-53KY5HU6FR
B1280
NSC91532
EN300-21325
MFCD00005316
DTXSID9062805
HY-W001223
bromo-thiazole
EINECS 221-229-4

MDL Number

MFCD00005316

Customs Code

29341000

FAQ

What are the physical and chemical properties of 2-Bromo-1,3-thiazole (CAS: 3034-53-5)?

2-Bromo-1,3-thiazole (CAS: 3034-53-5) is a crystalline solid with a molecular weight of 165.01 g/mol. It has a low solubility in water (0.05 g/100 mL at 20°C) and exhibits good solubility in organic solvents like acetone and dimethyl sulfoxide. This compound is known for its high reactivity towards nucleophiles, particularly in the presence of amines and thiols.

How is 2-Bromo-1,3-thiazole (CAS: 3034-53-5) typically synthesized?

2-Bromo-1,3-thiazole (CAS: 3034-53-5) is typically synthesized through the bromination of 1,3-thiazole using N-bromosuccinimide (NBS) in the presence of a suitable initiator such as benzoyl peroxide. The reaction is carried out under anhydrous conditions to enhance selectivity and yield.

What industries use 2-Bromo-1,3-thiazole (CAS: 3034-53-5)?

2-Bromo-1,3-thiazole (CAS: 3034-53-5) finds applications in various industries, including pharmaceuticals, where it serves as a precursor for synthesizing medicinal compounds; polymers, where it can be used as a stabilizer; sensors, where its reactivity can be utilized for detection purposes; and semiconductors, where its properties can contribute to the development of advanced materials.

What precautions should be taken when handling 2-Bromo-1,3-thiazole (CAS: 3034-53-5)?

When handling 2-Bromo-1,3-thiazole (CAS: 3034-53-5), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. This compound should be used in a well-ventilated area or a fume hood to minimize inhalation risks. Proper spill handling procedures should be followed, and safety data sheets (SDS) should be consulted for detailed information on safe handling practices.