Progesterone Acetate

Basic Information

View in Editor

CAS Number

302-23-8

Molecular Formula

C23H32O4

Molecular Weight

372.51 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

Physical State

Powder

Melting Point

244.0 to 248.0 deg-C

Boiling Point

490.2°C at 760 mmHg

Refractive Index

1.4433 (estimate)

SMILES

View in Editor

CC(=O)C1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)OC(=O)C

InChI

InChI=1S/C23H32O4/c1-14(24)23(27-15(2)25)12-9-20-18-6-5-16-13-17(26)7-10-21(16,3)19(18)8-11-22(20,23)4/h13,18-20H,5-12H2,1-4H3/t18-,19+,20+,21+,22+,23+/m1/s1

InChIKey

VTHUYJIXSMGYOQ-KOORYGTMSA-N

LogP

4.409200000000004

Topological Polar Surface Area

60.440000000000005 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Complexity

737

Safety Information

View Safety Information

GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

302-23-8
NSC 12191
17.alpha.-Acetoxyprogesterone
17alpha-Acetoxy-4-pregnene-3,20-dione
17-Acetoxyprogesterone
DTXSID90894096
17alpha-acetoxy-progesterone
BCPP000210
Chlormadinone acetate impurity G, European Pharmacopoeia (EP) Reference Standard
EC 206-119-6
CHEBI:197158
17-Hydroxypregn-4-ene-3,20-dioneacetate
3,20-DIOXOPREGN-4-EN-17-YL ACETATE [WHO-IP]
3,20-Dioxopregn-4-en-17-yl acetate
MEDROXYPROGESTERONE ACETATE IMPURITY H [WHO-IP]
HY-N0347
17alpha-Acetoxypregnen-4-en-3,20-dion
HYDROXYPROGESTERONE ACETATE [WHO-DD]
DS-11426
HYDROXYPROGESTERONE ACETATE [WHO-IP]
17.alpha.-Hydroxy-4-pregnene-3,20-dione 17-acetate
H1527
4-Pregnen-17.alpha.-ol-3,20-dione acetate
SCHEMBL260023
U5533
EINECS 206-119-6
NS00084998
Prodox acetate
NSC-12191
hydroxyprogesterone-acetate
Acetoxyprogesterone

MDL Number

MFCD00021152

FAQ

What are the physical and chemical properties of Progesterone Acetate (CAS: 302-23-8)?

Progesterone Acetate is a white to off-white crystalline powder. It has a molecular weight of approximately 342.44 g/mol. It is sparingly soluble in water and freely soluble in organic solvents such as methanol and ethanol. Progesterone Acetate is stable under normal conditions but may react with strong acids or bases, leading to hydrolysis. It is also sensitive to light and should be stored in a cool, dark place.

How is Progesterone Acetate (CAS: 302-23-8) typically synthesized?

Progesterone Acetate is synthesized by the acetylation of progesterone. The acetylation is typically catalyzed by acetic anhydride and a strong base such as sodium hydroxide. The reaction is carried out in an organic solvent like dichloromethane. The yield is usually around 85-90%, and the reaction is selective for the acetylation of progesterone.

What industries use Progesterone Acetate (CAS: 302-23-8)?

Progesterone Acetate is primarily used in the pharmaceutical industry for the production of contraceptive pills and hormonal therapies. It is also used in veterinary medicine for animal reproduction control. Additionally, it finds applications in the research and development of new drugs and in some cosmetic products for its hormonal effects.

What precautions should be taken when handling Progesterone Acetate (CAS: 302-23-8)?

Progesterone Acetate should be handled in a well-ventilated area and with proper personal protective equipment (PPE) such as gloves and safety goggles. It should be stored away from heat and light sources. In the event of a spill, it should be handled using appropriate spill response materials. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.