1-(2-Chloro-5-fluorophenyl)ethanone

Basic Information

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CAS Number

2965-16-4

Molecular Formula

C8H6ClFO

Molecular Weight

172.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

82°C/5mmHg

Density

1.258

Flash Point

75.9℃

Refractive Index

1.5200 to 1.5240

SMILES

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CC(=O)C1=C(C=CC(=C1)F)Cl

InChI

InChI=1S/C8H6ClFO/c1-5(11)7-4-6(10)2-3-8(7)9/h2-4H,1H3

InChIKey

KDBNPMAKHFSEBH-UHFFFAOYSA-N

LogP

2.681700000000001

Topological Polar Surface Area

17.07 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

160

Safety Information

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Hazard Statement

H227 Combustible liquid
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

CS-W002212
2'-Chloro-5'-fluoroacetophenone
2-chloro-5-fluoro acetophenone
1-(2-chloro-5-fluorophenyl)ethanone
FT-0634581
2`-Chloro-5`-fluoroacetophenone
2965-16-4
Ethanone, 1-(2-chloro-5-fluorophenyl)-
1-(2-chloranyl-5-fluoranyl-phenyl)ethanone
EN300-1981290
AKOS005063625
2-Chloro-5-fluoroacetophenone
AC-2846
SCHEMBL5884181
2'-chloro-5'-fluoroacetophenone, AldrichCPR
1-(2-chloro-5-fluorophenyl)ethan-1-one
AM20050174
DTXSID30371412
AC-3613
C3297
SY003104
2 inverted exclamation mark -Chloro-5 inverted exclamation mark -fluoroacetophenone
A819990
PS-8656
MFCD00042574
1-(2-Chloro-5-fluorophenyl)ethanone
2-Chloro-5-Fluoroacetophenone
Ethanone,1-(2-chloro-5-fluorophenyl)-
1-(2-chloro-5-fluoro-phenyl)-ethanone
2-Chlor-5-fluor-acetophenon
2'-Chloro-5'-fluoro acetophenone

MDL Number

MFCD00042574

Customs Code

2914700090

FAQ

What are the physical and chemical properties of 1-(2-Chloro-5-fluorophenyl)ethanone (CAS: 2965-16-4)?

1-(2-Chloro-5-fluorophenyl)ethanone (CAS: 2965-16-4) is a white crystalline solid with a molecular weight of approximately 222.59 g/mol. It is slightly soluble in water and more soluble in organic solvents like acetone and chloroform. The compound shows good reactivity towards nucleophiles and electrophiles, making it useful in various synthetic reactions.

How is 1-(2-Chloro-5-fluorophenyl)ethanone (CAS: 2965-16-4) typically synthesized?

1-(2-Chloro-5-fluorophenyl)ethanone (CAS: 2965-16-4) is commonly synthesized via the reaction of 2-chloro-5-fluorophenylacetonitrile with hydroiodic acid, followed by hydrolysis to form the ketone. The reaction is selective and yields up to 95% pure product under optimized conditions.

What industries use 1-(2-Chloro-5-fluorophenyl)ethanone (CAS: 2965-16-4)?

1-(2-Chloro-5-fluorophenyl)ethanone (CAS: 2965-16-4) is primarily used in the pharmaceutical and chemical industries for the synthesis of intermediates and active pharmaceutical ingredients. It also has potential applications in polymer synthesis and as a sensor material.

What precautions should be taken when handling 1-(2-Chloro-5-fluorophenyl)ethanone (CAS: 2965-16-4)?

When handling 1-(2-Chloro-5-fluorophenyl)ethanone (CAS: 2965-16-4), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a dry, well-ventilated area, preferably under a fume hood. In case of spill, contain the material with absorbent paper and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.