tert-Butyl (1-acetylpiperidin-4-yl)carbamate

Basic Information

View in Editor

CAS Number

283167-28-2

Molecular Formula

C12H22N2O3

Molecular Weight

242.32 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

SMILES

View in Editor

CC(=O)N1CCC(CC1)NC(=O)OC(C)(C)C

InChI

InChI=1S/C12H22N2O3/c1-9(15)14-7-5-10(6-8-14)13-11(16)17-12(2,3)4/h10H,5-8H2,1-4H3,(H,13,16)

InChIKey

YBNZMQXSIQUIHZ-UHFFFAOYSA-N

LogP

1.5219999999999996

Topological Polar Surface Area

58.64 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

289

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

tert-butyl N-(1-acetylpiperidin-4-yl)carbamate
4-BOC-amino-1-acetylpiperidine
SureCN89460
1-Acetyl-4-boc-amino-piperidine
T6736342
KB-259977
I12-0426
tert-Butyl (1-acetylpiperidin-4-yl)carbamate
tert-butyl 1-acetylpiperidin-4-ylcarbamate
1-Acetyl-4-Bocamino-piperidine
1-Acetyl-4-(Boc-amino)piperidine
YBNZMQXSIQUIHZ-UHFFFAOYSA-N
1-Acetyl-(4-BOC-amino)piperidine
SY045894
AK158089
tert-butyl(1-acetylpiperidin-4-yl)carbamate
O-tert-butyl (1-acetylpipe
283167-28-2
DS-9322
MFCD11844779
SCHEMBL89460
CS-D0547
AKOS010197253
AB8506
Z654814936
DB-103111
DTXSID60627979
O-tert-butyl (1-acetylpiperidin-4-yl)carbamate
O-tert-butyl N-(1-acetylpiperidin-4-yl)carbamate

MDL Number

MFCD11844779

Customs Code

2933399090

FAQ

What are the physical and chemical properties of tert-Butyl (1-acetylpiperidin-4-yl)carbamate (CAS: 283167-28-2)?

tert-Butyl (1-acetylpiperidin-4-yl)carbamate is a white crystalline solid with a molecular weight of approximately 280.42 g/mol. It has a low solubility in water but is more soluble in organic solvents like dichloromethane and acetone. This compound is moderately reactive, particularly towards nucleophiles. It can also undergo hydrolysis under basic conditions.

How is tert-Butyl (1-acetylpiperidin-4-yl)carbamate (CAS: 283167-28-2) typically synthesized?

tert-Butyl (1-acetylpiperidin-4-yl)carbamate is typically synthesized by the reaction of tert-butyl piperidin-4-ylcarbamate with acetic anhydride in the presence of a catalytic amount of a base such as pyridine. The reaction is carried out at room temperature, and the product is isolated by column chromatography. This method provides a yield of around 85%.

What industries use tert-Butyl (1-acetylpiperidin-4-yl)carbamate (CAS: 283167-28-2)?

tert-Butyl (1-acetylpiperidin-4-yl)carbamate is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds application in the chemical and polymer industries due to its functionality and reactivity. Additionally, it plays a role in the development of sensors and other specialized chemical products.

What precautions should be taken when handling tert-Butyl (1-acetylpiperidin-4-yl)carbamate (CAS: 283167-28-2)?

When handling tert-Butyl (1-acetylpiperidin-4-yl)carbamate, it is important to wear appropriate personal protective equipment (PPE), including gloves, safety glasses, and a lab coat. It should be handled in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate chemical spill kits, and the material safety data sheet (MSDS) should be consulted for proper disposal and emergency procedures.