7-Bromo-1-methyl-1H-indole

Basic Information

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CAS Number

280752-68-3

Molecular Formula

C9H8BrN

Molecular Weight

210.07 g/mol

Basic Physical Properties

Melting Point

50.5-53°C

Boiling Point

300.878°C at 760 mmHg

Density

1.472

Flash Point

135.766°C

Refractive Index

1.622

SMILES

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CN1C=CC2=C1C(=CC=C2)Br

InChI

InChI=1S/C9H8BrN/c1-11-6-5-7-3-2-4-8(10)9(7)11/h2-6H,1H3

InChIKey

CALOMHQMSHLUJX-UHFFFAOYSA-N

LogP

2.940800000000001

Topological Polar Surface Area

4.93 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

149

Synonyms & References

English

EN300-1911328
1H-Indole,7-bromo-1-methyl-
SY229686
PS-3774
F70985
7-BROMO-1-METHYL-1H-INDOLE 97%
CALOMHQMSHLUJX-UHFFFAOYSA-N
7-bromo-1-methylindole
280752-68-3
7-Bromo-1-methyl-1H-indole
1-methyl-7-bromoindole
AKOS022691514
MFCD09879960
DTXSID70620633
CS-0055870
FT-0729666
SCHEMBL2178459
1H-Indole,7-bromo-1-methyl
7-bromo-1-methyl-1H-indazole
7-bromo-N-methylindole
N-methyl-7-bromoindole
7-bromo-1-methyl-indole

MDL Number

MFCD09879960

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 7-Bromo-1-methyl-1H-indole (CAS: 280752-68-3)?

7-Bromo-1-methyl-1H-indole is a crystalline compound with a molecular weight of approximately 230.04 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and dichloromethane. The compound is moderately reactive, especially under basic conditions. It is stable under normal storage conditions but should be protected from light and moisture.

How is 7-Bromo-1-methyl-1H-indole (CAS: 280752-68-3) typically synthesized?

7-Bromo-1-methyl-1H-indole is typically synthesized via the bromination of 1-methylindole using N-bromosuccinimide (NBS) as the brominating agent. The reaction is carried out in a solvent such as dichloromethane. The yield is usually around 70-80%, and the selectivity is good, leading to the brominated product with high purity.

What industries use 7-Bromo-1-methyl-1H-indole (CAS: 280752-68-3)?

7-Bromo-1-methyl-1H-indole is used in the pharmaceutical industry for the synthesis of certain bioactive compounds. It is also explored in the sensor industry for its potential as a selective and sensitive detection material. Additionally, it has potential applications in the polymer industry for the development of new materials with specific properties.

What precautions should be taken when handling 7-Bromo-1-methyl-1H-indole (CAS: 280752-68-3)?

When handling 7-Bromo-1-methyl-1H-indole, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be handled with caution using appropriate absorbents. Always refer to the Safety Data Sheet (SDS) for detailed emergency protocols and storage recommendations.