piperazine-2-carboxylic acid

Basic Information

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CAS Number

2762-32-5

Molecular Formula

C5H10N2O2

Molecular Weight

130.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

291-293 ºC (dec.)

Boiling Point

313.6°Cat760mmHg

Flash Point

143.5℃

SMILES

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C1CNC(CN1)C(=O)O

InChI

InChI=1S/C5H10N2O2/c8-5(9)4-3-6-1-2-7-4/h4,6-7H,1-3H2,(H,8,9)

InChIKey

JSSXHAMIXJGYCS-UHFFFAOYSA-N

LogP

-1.3675999999999995

Topological Polar Surface Area

61.36 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

116

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

SB40749
FT-0601267
3-cyclohexene-1-carboxylicacid
2-carboxypiperazine
FT-0647739
(+/-)-Piperazine-2-carboxylic acid
(R)-(+)-Piperazine-2-carboxylic acid
FT-0650086
FT-0650082
FT-0605215
CS-W002409
2762-32-5
AKOS005068016
AC-2564
Q-201587
MFCD00132878
JSSXHAMIXJGYCS-UHFFFAOYSA-N
2-Piperazine carboxylic acid
FT-0650093
DS-1093
A819141
Piperazine-2-carboxylic acid
J-502517
SY002071
SCHEMBL162294
AB08722
2-piperazinecarboxylic acid
F0001-0887
SB11107
DTXSID70369095
EN300-67059

MDL Number

MFCD00132878

Customs Code

2933599090

FAQ

What are the physical and chemical properties of piperazine-2-carboxylic acid (CAS: 2762-32-5)?

Piperazine-2-carboxylic acid (CAS: 2762-32-5) is a colorless or white crystalline solid with a molecular weight of approximately 154.14 g/mol. It is slightly soluble in water and has a pKa of about 4.3. The compound reacts readily with bases and can form salts with various cations. It is stable under normal conditions but should be stored in a dry environment to prevent hydrolysis.

How is piperazine-2-carboxylic acid (CAS: 2762-32-5) typically synthesized?

Piperazine-2-carboxylic acid can be synthesized by the reaction of piperazine with carbon dioxide. Commonly, this involves the reaction of piperazine with carbon dioxide in the presence of a base, such as sodium carbonate, at elevated temperatures. The process typically yields high selectivity and good yield, with the product being isolated by crystallization.

What industries use piperazine-2-carboxylic acid (CAS: 2762-32-5)?

Piperazine-2-carboxylic acid (CAS: 2762-32-5) finds applications in various industries, including pharmaceuticals, where it is used as a precursor in the synthesis of drugs. It is also used in the production of polymers, sensors, and as a chelating agent in semiconductor processes. Its ability to form stable complexes with metal ions makes it valuable in these applications.

What precautions should be taken when handling piperazine-2-carboxylic acid (CAS: 2762-32-5)?

When handling piperazine-2-carboxylic acid (CAS: 2762-32-5), it is important to use personal protective equipment (PPE) such as gloves and safety goggles. Work should be carried out in a well-ventilated area or a fume hood. Spills should be cleaned up immediately with appropriate absorbent materials, and the area should be rinsed with water. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage. It is also advisable to avoid contact with skin and eyes and to have an emergency shower and eyewash station available.