piperazine-2-carboxylic acid(CAS: 2762-32-5)

Piperazine-2-carboxylic acid (CAS: 2762-32-5) is a colorless or white crystalline solid with a molecular weight of approximately 154.14 g/mol. It is slightly soluble in water and has a pKa of about 4.3. The compound reacts readily with bases and can form salts with various cations. It is stable under normal conditions but should be stored in a dry environment to prevent hydrolysis.

Piperazine-2-carboxylic acid can be synthesized by the reaction of piperazine with carbon dioxide. Commonly, this involves the reaction of piperazine with carbon dioxide in the presence of a base, such as sodium carbonate, at elevated temperatures. The process typically yields high selectivity and good yield, with the product being isolated by crystallization.

Piperazine-2-carboxylic acid (CAS: 2762-32-5) finds applications in various industries, including pharmaceuticals, where it is used as a precursor in the synthesis of drugs. It is also used in the production of polymers, sensors, and as a chelating agent in semiconductor processes. Its ability to form stable complexes with metal ions makes it valuable in these applications.

When handling piperazine-2-carboxylic acid (CAS: 2762-32-5), it is important to use personal protective equipment (PPE) such as gloves and safety goggles. Work should be carried out in a well-ventilated area or a fume hood. Spills should be cleaned up immediately with appropriate absorbent materials, and the area should be rinsed with water. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage. It is also advisable to avoid contact with skin and eyes and to have an emergency shower and eyewash station available.