(2S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide

Basic Information

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CAS Number

27262-40-4

Molecular Formula

C14H20N2O

Molecular Weight

232.33 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

Powder

Melting Point

129.0 to 133.0 deg-C

Boiling Point

392.3°C at 760 mmHg

Flash Point

149 ºC

Specific Rotation

+47.0 to +51.0° (c=1, 1N HCl)

SMILES

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CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2

InChI

InChI=1S/C14H20N2O/c1-10-6-5-7-11(2)13(10)16-14(17)12-8-3-4-9-15-12/h5-7,12,15H,3-4,8-9H2,1-2H3,(H,16,17)/t12-/m0/s1

InChIKey

SILRCGDPZGQJOQ-LBPRGKRZSA-N

LogP

2.3840400000000006

Topological Polar Surface Area

41.13 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

257

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(2S)-N-(2,6-DIMETHYLPHENYL)-2-PIPERIDINECARBOXAMIDE
(S)-N-(2',6'-Dimethylphenyl)-2-piperidine carboxamide
(S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide
(2S)-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
Q27149622
AKOS015919828
FS-2874
NS00116486
(S)-2',6'-Pipecoloxylidide
L-Pipecolic acid 2,6-xylidide
Demethylmepivacaine, (+)-
AC-2122
MFCD09038786
Desbutylbupivacaine, (+)-
SCHEMBL2616379
(S)-N-(2',6'-Dimethylphenyl)piperidine-2-carboxylic amide
AKOS030228178
D4347
(S)-N-(2,6-Dimethylphenyl)piperidine-2-carboxamide
(+)-2',6'-pipecoloxylidide
2',6'-Pipecoloxylidide, (+)-
(S)-N-(2 inverted exclamation marka,6 inverted exclamation marka-dimethylphenl)-2-Piperidine Carboxamide
Q-100343
ROPIVACAINE HYDROCHLORIDE MONOHYDRATE IMPURITY B [EP IMPURITY]
2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-, (2S)-
DTXSID10181713
N-Despropyl Ropivacaine
CHEBI:80578
UNII-4A8HC6M4AL
CS-W003585
4A8HC6M4AL

MDL Number

MFCD09038786

FAQ

What are the physical and chemical properties of (2S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide (CAS: 27262-40-4)?

(2S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide is a white or off-white crystalline solid with a molecular weight of approximately 296.41 g/mol. It has a melting point of 145-146°C and is slightly soluble in water but more soluble in organic solvents like ethanol and dimethylformamide. The compound is known for its good stability and low reactivity under normal conditions. It does not readily undergo hydrolysis or other degradation reactions under typical laboratory conditions.

How is (2S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide (CAS: 27262-40-4) typically synthesized?

(2S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide is synthesized through a multi-step process involving condensation reactions. The synthesis typically starts with 2,6-dimethylbenzaldehyde and piperidine, which are reacted under basic conditions to form the carboxamide. This process is highly selective and yields up to 90% of the desired product with minimal side products. The reaction conditions, such as temperature and solvent, play a crucial role in achieving high yield and purity.

What industries use (2S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide (CAS: 27262-40-4)?

(2S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the polymer industry as a stabilizer and in the sensor industry for its ability to detect specific chemical compounds. Additionally, it can be used in semiconductors as a dopant. Its versatile chemical properties and reactivity make it valuable in multiple industrial sectors.

What precautions should be taken when handling (2S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide (CAS: 27262-40-4)?

When handling (2S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be used in a well-ventilated area or a fume hood to minimize inhalation and skin contact. In case of a spill, it is recommended to clean it up using appropriate absorbent materials and follow proper waste disposal procedures. Always refer to the Safety Data Sheet (SDS) for the most current handling and storage information.