1H-Pyrazolo[4,3-b]pyridine

Basic Information

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CAS Number

272-52-6

Molecular Formula

C6H5N3

Molecular Weight

119.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

294.5℃ at 760 mmHg

Density

1.349

Flash Point

294.466 °C at 760 mmHg

Refractive Index

1.715

SMILES

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C1=CC2=C(C=NN2)N=C1

InChI

InChI=1S/C6H5N3/c1-2-5-6(7-3-1)4-8-9-5/h1-4H,(H,8,9)

InChIKey

AMFYRKOUWBAGHV-UHFFFAOYSA-N

LogP

0.9578999999999999

Topological Polar Surface Area

41.57 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

105

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

DTXSID10949931
AMFYRKOUWBAGHV-UHFFFAOYSA-N
Pyrazolo[4,3-b]pyridine
EN300-103560
SY008431
1H-pyrazolo[4,3-b]pyridine
CS-W003469
MFCD08234560
272-51-5
F18246
J-504739
AKOS006280755
A15441
PB32568
FT-0651102
PS-4751
SCHEMBL10290
Z2236735376
2H-PYRAZOLO[4,3-B]PYRIDINE
1H-pyrazolo[4, 3-b]pyridine
BCP26437
AM20051026
272-52-6
PYRAZOLOPYRIDINE
1H-Pyrazolo[4 pound not3-b]pyridine
AKOS016003571
1H-Pyrazolo[4,3-b]pyridine, AldrichCPR
1H-PYRAZOLO[4,3-B]PYRIDINE
pyridopyrazole
4-Aza-1H-indazole
PubChem19278

MDL Number

MFCD08234560

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 1H-Pyrazolo[4,3-b]pyridine (CAS: 272-52-6)?

1H-Pyrazolo[4,3-b]pyridine is a solid with a crystalline form. Its molecular weight is approximately 159.15 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetone. Chemically, it is moderately reactive, particularly towards nucleophiles and electrophiles. It is often used as a precursor in the synthesis of other biological and pharmaceutical compounds.

How is 1H-Pyrazolo[4,3-b]pyridine (CAS: 272-52-6) typically synthesized?

1H-Pyrazolo[4,3-b]pyridine can be synthesized through the condensation of 2-pyridone and furan using a catalyst like p-toluenesulfonic acid (ptSA). This method provides good yields and selectivity. Other routes include the use of 2-pyridone and 2-furylboronic acid in a Pd-catalyzed cross-coupling reaction, which is also effective.

What industries use 1H-Pyrazolo[4,3-b]pyridine (CAS: 272-52-6)?

1H-Pyrazolo[4,3-b]pyridine is primarily used in the pharmaceutical industry as a precursor for drug development. It is also explored in the sensor industry for its potential in detecting specific analytes. Additionally, it has applications in the semiconductor industry for certain electronic applications.

What precautions should be taken when handling 1H-Pyrazolo[4,3-b]pyridine (CAS: 272-52-6)?

When handling 1H-Pyrazolo[4,3-b]pyridine, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for comprehensive safety guidelines.