1H-Pyrazolo[4,3-b]pyridine(CAS: 272-52-6)

1H-Pyrazolo[4,3-b]pyridine is a solid with a crystalline form. Its molecular weight is approximately 159.15 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetone. Chemically, it is moderately reactive, particularly towards nucleophiles and electrophiles. It is often used as a precursor in the synthesis of other biological and pharmaceutical compounds.

1H-Pyrazolo[4,3-b]pyridine can be synthesized through the condensation of 2-pyridone and furan using a catalyst like p-toluenesulfonic acid (ptSA). This method provides good yields and selectivity. Other routes include the use of 2-pyridone and 2-furylboronic acid in a Pd-catalyzed cross-coupling reaction, which is also effective.

1H-Pyrazolo[4,3-b]pyridine is primarily used in the pharmaceutical industry as a precursor for drug development. It is also explored in the sensor industry for its potential in detecting specific analytes. Additionally, it has applications in the semiconductor industry for certain electronic applications.

When handling 1H-Pyrazolo[4,3-b]pyridine, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for comprehensive safety guidelines.