Methyl 6-bromo-2-pyridinecarboxylate

Basic Information

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CAS Number

26218-75-7

Molecular Formula

C7H6BrNO2

Molecular Weight

216.03 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

93.0 to 97.0 deg-C

Boiling Point

289.7℃ at 760 mmHg

Density

1.579

Flash Point

129.0±21.8 °C

Refractive Index

1.554

SMILES

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COC(=O)C1=NC(=CC=C1)Br

InChI

InChI=1S/C7H6BrNO2/c1-11-7(10)5-3-2-4-6(8)9-5/h2-4H,1H3

InChIKey

SGNCOKUHMXLGAH-UHFFFAOYSA-N

LogP

1.63070

Complexity

151

Safety Information

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GHS Hazard Pictograms

H315

H318

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

SCHEMBL38206
J-400969
Methyl-6-bromopyridine-2-carboxylate
Methyl6-bromopicolinate
DTXSID50584623
methyl 6-bromo-pyridine-2-carboxylate
A5207
Methyl 6-bromopicolinate
FT-0621003
6-bromo-pyridine-2-carboxylic acid methyl ester
SY009096
CS-M1028
6-Bromo-2-pyridine carboxylic acid methyl ester
SGNCOKUHMXLGAH-UHFFFAOYSA-N
Methyl-6-Bromo-2-Pyridine Carboxylate
2-PYRIDINECARBOXYLIC ACID, 6-BROMO-, METHYL ESTER
AKOS000279089
PS-4896
MFCD06203934
Methyl 6-bromopyridine-2-carboxylate
Methyl 6-BroMoyridine-2-carboxylate
BCP21665
HY-76562
6-Bromopicolinic acid methyl ester
methyl-6-bromo-pyridine-2-carboxylate
M2342
Methly 6-bromopyridine-2-carboxylate
Methyl 6-bromo-2-pyridinecarboxylate
6-Bromopyridine-2-carboxylic Acid Methyl Ester
methyl 2-bromopyridine-6-carboxylate
AC-24955

MDL Number

MFCD06203934

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Methyl 6-bromo-2-pyridinecarboxylate (CAS: 26218-75-7)?

Methyl 6-bromo-2-pyridinecarboxylate (CAS: 26218-75-7) is a crystalline solid with a molecular weight of approximately 228.03 g/mol. It has a low solubility in water but is soluble in most organic solvents. This compound is moderately reactive, particularly towards nucleophiles and reducing agents. It can form complexes with metal ions and may undergo nucleophilic substitution reactions.

How is Methyl 6-bromo-2-pyridinecarboxylate (CAS: 26218-75-7) typically synthesized?

Methyl 6-bromo-2-pyridinecarboxylate is typically synthesized through the reaction of methyl 2-pyridinecarboxylate with bromine in the presence of a base such as sodium hydroxide. This process yields the target compound with good selectivity and a yield of around 70-80%. The reaction is conducted at room temperature and under an inert atmosphere.

What industries use Methyl 6-bromo-2-pyridinecarboxylate (CAS: 26218-75-7)?

Methyl 6-bromo-2-pyridinecarboxylate (CAS: 26218-75-7) is primarily used in the pharmaceutical industry for the synthesis of intermediates and bioactive compounds. It also has applications in the polymer industry for the modification of polymer properties and in the semiconductor industry as a precursor for various materials.

What precautions should be taken when handling Methyl 6-bromo-2-pyridinecarboxylate (CAS: 26218-75-7)?

When handling Methyl 6-bromo-2-pyridinecarboxylate (CAS: 26218-75-7), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. The compound should be handled in a well-ventilated area or a fume hood to minimize exposure to bromine and other reaction byproducts. In case of a spill, use appropriate absorbent materials and follow the safety data sheet (SDS) for disposal instructions to ensure proper handling and environmental safety.